Do vaccinations influence the development of Alzheimer disease?

被引：10

作者：

Bukhbinder, Avram S. ^{[1
,2
]}

Ling, Yaobin ^{[3
]}

Harris, Kristofer ^{[1
]}

Jiang, Xiaoqian ^{[3
]}

Schulz, Paul E. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Neurol, Houston, TX 77054 USA

[2] Massachusetts Gen Hosp, Div Pediatr Neurol, Boston, MA USA

[3] Univ Texas Hlth Sci Ctr Houston, McWilliams Sch Biomed Informat, Houston, TX USA

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2023年 / 19卷 / 02期

关键词：

Vaccines; influenza vaccines; diphtheria-tetanus-acellular pertussis vaccines; pneumococcal vaccines; innate immunity; trained immunity; Alzheimer disease; dementia; neuroimmunomodulation; pharmacoepidemiology; APP/PS1; MICE;

D O I：

10.1080/21645515.2023.2216625

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A growing literature supports a protective association between vaccines targeting an array of pathogens (e.g., influenza, pneumococcus, herpes zoster) and the risk of Alzheimer disease (AD). This article discusses the potential underlying mechanisms for this apparent protective effect of immunizations against infectious pathogens on the risk of AD; explores the basic and pharmacoepidemiologic evidence for this association, with particular attention paid to important methodological variations among the epidemiologic studies; and reviews the remaining uncertainties regarding the effects of anti-pathogen vaccines on Alzheimer disease and all-cause dementia, with recommendations for future directions to address those uncertainties.

引用

页数：6

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