RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer Cells via ARPIN

被引：9

作者：

Park, Min Ji ^{[1
]}

Jeong, Eunji ^{[1
]}

Lee, Eun Ji ^{[1
]}

Choi, Hyeon Ji ^{[1
]}

Moon, Bo Hyun ^{[2
]}

Kang, Keunsoo ^{[3
]}

Chang, Suhwan ^{[1
,4
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Biomed Sci, Seoul 05505, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul 05505, South Korea

[3] Dankook Univ, Coll Sci & Technol, Dept Microbiol, Cheonan 31116, South Korea

[4] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Physiol, Seoul 05505, South Korea

来源：

MOLECULES AND CELLS | 2023年 / 46卷 / 06期

关键词：

ADAR1; ARPIN; breast cancer; metastasis; RNA editing; ARP2/3; COMPLEX; BREAST-CANCER; GENE; EXPRESSION; MUTATIONS; MIGRATION; INVASION; GROWTH;

D O I：

10.14348/molcells.2023.2174

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deamination of adenine or cytosine in RNA, called RNA editing, is a constitutively active and common modification. The primary role of RNA editing is tagging RNA right after its synthesis so that the endogenous RNA is recognized as self and distinguished from exogenous RNA, such as viral RNA. In addition to this primary function, the direct or indirect effects on gene expression can be utilized in cancer where a high level of RNA editing activity persists. This report identified actin-related protein 2/3 complex inhibitor (ARPIN) as a target of ADAR1 in breast cancer cells. Our comparative RNA sequencing analysis in MCF7 cells revealed that the expression of ARPIN was decreased upon ADAR1 depletion with altered editing on its 3'UTR. However, the expression changes of ARPIN were not dependent on 3'UTR editing but relied on three microRNAs acting on ARPIN. As a result, we cancer cell mobility via the upregulation of ARPIN.

引用

页码：351 / 359

页数：9

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