Epidemiologic and Clinical Outcomes of Pediatric Renal Tumors in Korea: A Retrospective Analysis of The Korean Pediatric Hematology and Oncology Group (KPHOG) Data

被引：0

作者：

Koh, Kyung-Nam ^{[1
]}

Han, Jung Woo ^{[2
]}

Choi, Hyoung Soo ^{[3
]}

Kang, Hyoung Jin ^{[4
,5
]}

Lee, Ji Won ^{[6
]}

Yoo, Keon Hee ^{[6
]}

Sung, Ki Woong ^{[6
]}

Koo, Hong Hoe ^{[6
]}

Hong, Kyung Taek ^{[4
,5
]}

Choi, Jung Yoon ^{[4
,5
]}

Kang, Sung Han ^{[1
]}

Kim, Hyery ^{[1
]}

Im, Ho Joon ^{[1
]}

Hahn, Seung Min ^{[2
]}

Lyu, Chuhl Joo ^{[2
]}

Baek, Hee-Jo ^{[7
]}

Kook, Hoon ^{[7
]}

Park, Kyung Mi ^{[8
,30
]}

Yang, Eu Jeen ^{[8
]}

Lim, Young Tak ^{[8
]}

Kim, Seongkoo ^{[8
,9
]}

Lee, Jae Wook ^{[9
]}

Chung, Nack-Gyun ^{[9
]}

Cho, Bin ^{[9
]}

Park, Meerim ^{[10
]}

Park, Hyeon Jin ^{[10
]}

Park, Byung-Kiu ^{[10
]}

Lee, Jun Ah ^{[10
,11
]}

Park, Jun Eun ^{[12
,31
]}

Kim, Soon Ki ^{[13
]}

Kim, Ji Yoon ^{[14
]}

Kim, Hyo Sun ^{[15
]}

Ma, Youngeun ^{[3
,8
]}

Park, Kyung Duk ^{[16
,17
]}

Park, Sang Kyu ^{[18
]}

Park, Eun Sil ^{[19
]}

Shim, Ye Jee ^{[20
]}

Yoo, Eun Sun ^{[21
]}

Ha Ryu, Kyung ^{[21
]}

Yoo, Jae Wo ^{[9
,22
]}

Lim, Yeon Jung ^{[22
]}

Yoon, Hoi Soo ^{[23
]}

Lee, Mee Jeong ^{[24
]}

Lee, Jae Min ^{[25
]}

Jeon, In-Sang ^{[26
]}

Jung, Hye Lim ^{[27
]}

Chueh, Hee Won ^{[28
]}

Won, Seunghyun ^{[29
]}

机构：

[1] Univ Ulsan, Asan Med Ctr Childrens Hosp, Dept Pediat, Div Pediat Hematol Oncol,Coll Med, Seoul, South Korea

[2] Yonsei Univ, Coll Med, Div Pediat Hematol & Oncol, Dept Pediat, Seoul, South Korea

[3] Seoul Natl Univ, Bundang Hosp, Dept Pediat, Coll Med, Seongnam, South Korea

[4] Seoul Natl Univ, Dept Pediat, Coll Med, Seoul, South Korea

[5] Seoul Natl Univ, Canc Inst, Seoul, South Korea

[6] Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea

[7] Chonnam Natl Univ, Hwasun Hosp, Dept Pediat, Med Sch, Gwangju, South Korea

[8] Pusan Natl Univ, Dept Pediat, Sch Med, Yangsan, South Korea

[9] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Pediat, Seoul, South Korea

[10] Natl Canc Ctr, Ctr Pediat Canc, Dept Pediat, Goyang, South Korea

[11] Korea Canc Ctr Hosp, Dept Pediat, Seoul, South Korea

[12] Korea Univ, Dept Pediat, Sch Med, Seoul, South Korea

[13] Inha Univ, Inha Univ Hosp, Dept Pediat, Coll Med, Incheon, South Korea

[14] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pediat, Daegu, South Korea

[15] Inje Univ, Haeundae Paik Hosp, Dept Pediat, Pusan, South Korea

[16] Jeonbuk Natl Univ, Dept Pediat, Med Sch, Jeonbuk Natl Univ Hosp, Jeonju, South Korea

[17] Jeonbuk Natl Univ, Res Inst Clin Med, Jeonbuk Natl Univ Hosp, Med Sch, Jeonju, South Korea

[18] Univ Ulsan, Ulsan Univ Hosp, Dept Pediat, Coll Med, Ulsan, South Korea

[19] Gyeongsang Natl Univ, Dept Pediat, Sch Med, Jinju, South Korea

[20] Keimyung Univ, Sch Med, Dept Pediat, Dongsan Hosp, Daegu, South Korea

[21] Ewha Womans Univ, Coll Med, Dept Pediat, Seoul Hosp, Seoul, South Korea

[22] Chungnam Natl Univ, Dept Pediat, Coll Med, Daejeon, South Korea

[23] Kyung Hee Univ, Dept Pediat, Coll Med, Seoul, South Korea

[24] Dankook Univ, Dept Pediat, Coll Med, Cheonan, South Korea

[25] Yeungnam Univ, Dept Pediat, Coll Med, Daegu, South Korea

[26] Gachon Univ, Dept Pediat, Gil Med Ctr, Incheon, South Korea

[27] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Pediat, Sch Med, Seoul, South Korea

[28] Dong A Univ, Dept Pediat, Coll Med, Pusan, South Korea

[29] Seoul Natl Univ, Med Res Collaborating Ctr, Bundang Hosp, Seongnam, South Korea

[30] Dongnam Inst Radiol & Med Sci, Dept Pediat, Busan, South Korea

[31] Korea Univ, Dept Pediat, Med Ctr, Seoul, South Korea

来源：

CANCER RESEARCH AND TREATMENT | 2023年 / 55卷 / 01期

关键词：

Kidney neoplasms; Child; Epidemiology; WILMS-TUMOR; KIDNEY; PROTOCOLS; TURNOURS; BIOLOGY;

D O I：

10.4143/crt.2022.073

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose Renal tumors account for approximately 7% of all childhood cancers. These include Wilms tumor (WT), clear cell sarcoma of the kidney (CCSK), malignant rhabdoid tumor of the kidney (MRTK), renal cell carcinoma (RCC), congenital mesoblastic nephroma (CMN) and other rare tumors. We investigated the epidemiology of pediatric renal tumors in Korea. Materials and Methods From January 2001 to December 2015, data of pediatric patients (0-18 years) newly-diagnosed with renal tumors at 26 hospitals were retrospectively analyzed.Results Among 439 patients (male, 240), the most common tumor was WT (n=342, 77.9%), followed by RCC (n=36, 8.2%), CCSK (n=24, 5.5%), MRTK (n=16, 3.6%), CMN (n=12, 2.7%), and others (n=9, 2.1%). Median age at diagnosis was 27.1 months (range, 0 to 225.5 months) and median follow-up duration was 88.5 months (range, 0 to 211.6 months). Overall, 32 patients died, of whom 17, 11, 1, and three died of relapse, progressive disease, second malignant neoplasm, and treatment-related mortality. Five-year overall survival and event-free survival were 97.2% and 84.8% in WT, 90.6% and 82.1% in RCC, 81.1% and 63.6% in CCSK, 60.3% and 56.2% in MRTK, and 100% and 91.7% in CMN, respectively (p < 0.001).Conclusion The pediatric renal tumor types in Korea are similar to those previously reported in other countries. WT accounted for a large proportion and survival was excellent. Non-Wilms renal tumors included a variety of tumors and showed inferior outcome, especially MRTK. Further efforts are necessary to optimize the treatment and analyze the genetic characteristics of pediatric renal tumors in Korea.

引用

页码：279 / 290

页数：12

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