Polymer Translocation

被引:6
作者
Lu, Lu-Wei [1 ,2 ]
Wang, Zhen-Hua [1 ]
Shi, An-Chang [3 ]
Lu, Yu-Yuan [1 ,2 ]
An, Li-Jia [1 ,2 ]
机构
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
[2] Univ Sci & Technol China, Hefei 230026, Peoples R China
[3] McMaster Univ, Dept Phys & Astron, Hamilton, ON L8S 4M1, Canada
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
Polymer translocation; Knotted polymers; Translocation time; Critical flux; GLYCINE-RICH REGION; DNA EJECTION; FLEXIBLE POLYMERS; CONFINED POLYMER; NANOPORE SENSORS; CHAIN PASS; PROTEIN; DYNAMICS; FORCES; KNOTS;
D O I
10.1007/s10118-023-2975-6
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The translocation of a polymer through a pore that is much smaller than its size is a fundamental and actively researched topic in polymer physics. An understanding of the principles governing polymer translocation provides important guidance for various practical applications, such as the separation and purification of polymers, nanopore-based single-molecule deoxyribonucleic acid/ribonucleic acid(DNA/RNA) sequencing, transmembrane transport of DNA or RNA, and infection of bacterial cells by bacteriophages. The past several decades have seen great progresses on the study of polymer translocation. Here we present an overview of theoretical, experimental, and simulational stduies on polymer translocation, focusing on the roles played by several important factors, including initial polymer conformations, external fields, polymer topology and architectures, and confinement degree. We highlight the physical mechanisms of different types of polymer translocations, and the main controversies about the basic rules of translocation dynamics. We compare and contrast the behaviors of force-induced versus flow-induced translocations and the effects of unknotted versus knotted polymers. Finally, we mention several opportunities and challenges in the study of polymer translocation.
引用
收藏
页码:683 / 698
页数:16
相关论文
共 134 条
[51]   Polymer Translocation Time [J].
Lu, Yuyuan ;
Wang, Zhenhua ;
An, Lijia ;
Shi, An-Chang .
JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2021, 12 (47) :11534-11542
[52]   Intrinsic Viscosity of Polymers: General Theory Based on a Partially Permeable Sphere Model [J].
Lu, Yuyuan ;
An, Lijia ;
Wang, Zhen-Gang .
MACROMOLECULES, 2013, 46 (14) :5731-5740
[53]   Driven polymer translocation through a narrow pore [J].
Lubensky, DK ;
Nelson, DR .
BIOPHYSICAL JOURNAL, 1999, 77 (04) :1824-1838
[54]   Polymer translocation through a nanopore: A two-dimensional Monte Carlo study [J].
Luo, K ;
Ala-Nissila, T ;
Ying, SC .
JOURNAL OF CHEMICAL PHYSICS, 2006, 124 (03)
[55]   Driven polymer translocation through nanopores: Slow-vs.-fast dynamics [J].
Luo, K. ;
Ala-Nissila, T. ;
Ying, S. -C. ;
Metzler, R. .
EPL, 2009, 88 (06)
[56]   Influence of polymer-pore interactions on translocation [J].
Luo, Kaifu ;
Ala-Nissila, Tapio ;
Ying, See-Chen ;
Bhattacharya, Aniket .
PHYSICAL REVIEW LETTERS, 2007, 99 (14)
[57]   Dynamical scaling exponents for polymer translocation through a nanopore [J].
Luo, Kaifu ;
Ollila, Santtu T. T. ;
Huopaniemi, Ilkka ;
Ala-Nissila, Tapio ;
Pomorski, Pawel ;
Karttunen, Mikko ;
Ying, See-Chen ;
Bhattacharya, Aniket .
PHYSICAL REVIEW E, 2008, 78 (05)
[58]   Polymer translocation through a nanopore under an applied external field [J].
Luo, KF ;
Huopaniemi, I ;
Ala-Nissila, T ;
Ying, SC .
JOURNAL OF CHEMICAL PHYSICS, 2006, 124 (11)
[59]   Folding studies on a knotted protein [J].
Mallam, AL ;
Jackson, SE .
JOURNAL OF MOLECULAR BIOLOGY, 2005, 346 (05) :1409-1421
[60]   Real-time imaging of DNA ejection from single phage particles [J].
Mangenot, S ;
Hochrein, M ;
Rädler, J ;
Letellier, L .
CURRENT BIOLOGY, 2005, 15 (05) :430-435