Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with Renal Failure

被引:11
作者
Lopez-Baltanas, Rodrigo [1 ]
Rodriguez-Ortiz, Maria E. [1 ,2 ]
Diaz-Tocados, Juan M. [3 ]
Martinez-Moreno, Julio M. [1 ]
Membrives, Cristina [1 ]
Rodelo-Haad, Cristian [2 ,4 ]
Ruiz de Mier, M. Victoria Pendon [2 ,4 ]
Rodriguez, Mariano [2 ,4 ]
Canalejo, Antonio [5 ]
Almaden, Yolanda [1 ]
Munoz-Castaneda, Juan R. [2 ,4 ]
机构
[1] Univ Cordoba, Reina Sofia Univ Hosp, Inst Maimonides Invest Biomed Cordoba IMIB, Cordoba 14004, Spain
[2] Inst Salud Carlos III, Redes Invest Cooperat Orientadas Resultados Salud, Madrid 28029, Spain
[3] Arnau de Vilanova Univ Hosp, Biomed Res Inst Lleida IRBLleida, Vasc & Renal Translat Res Grp, Lleida 25198, Spain
[4] Univ Cordoba, Reina Sofia Univ Hosp, Un Gest Clin Nefrol, Inst Maimonides Invest Biomed Cordoba IMIB, Cordoba 14004, Spain
[5] Univ Huelva, Res Ctr Nat Resources Hlth & Environm RENSMA, Dept Integrated Sci, Huelva 21007, Spain
关键词
magnesium; metabolic syndrome; chronic kidney disease; inflammation; oxidative stress; vascular dysfunction; CHRONIC KIDNEY-DISEASE; GLUTATHIONE-PEROXIDASE; CARDIOVASCULAR-DISEASE; CYSTATIN-C; MAGNESIUM; RISK; METAANALYSIS; KLOTHO; PROGRESSION; PREVENTION;
D O I
10.3390/antiox12020283
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Metabolic syndrome (MetS) and chronic kidney disease (CKD) are commonly associated with cardiovascular disease (CVD) and in these patients Mg concentration is usually decreased. This study evaluated whether a dietary Mg supplementation might attenuate vascular dysfunction through the modulation of oxidative stress and inflammation in concurrent MetS and CKD. Methods: A rat model of MetS (Zucker strain) with CKD (5/6 nephrectomy, Nx) was used. Nephrectomized animals were fed a normal 0.1%Mg (MetS+Nx+Mg0.1%) or a supplemented 0.6%Mg (MetS+Nx+Mg0.6%) diet; Sham-operated rats with MetS receiving 0.1%Mg were used as controls. Results: As compared to controls, the MetS+Nx-Mg0.1% group showed a significant increase in oxidative stress and inflammation biomarkers (lipid peroxidation and aortic interleukin-1b and -6 expression) and Endothelin-1 levels, a decrease in nitric oxide and a worsening in uremia and MetS associated pathology as hypertension, and abnormal glucose and lipid profile. Moreover, proteomic evaluation revealed changes mainly related to lipid metabolism and CVD markers. By contrast, in the MetS+Nx+Mg0.6% group, these parameters remained largely similar to controls. Conclusion: In concurrent MetS and CKD, dietary Mg supplementation reduced inflammation and oxidative stress and improved vascular function.
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页数:20
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