Nivolumab-induced radiation recall pneumonitis in non-small-cell lung cancer patients with thoracic radiation therapy

被引：2

作者：

Noda-Narita, Shoko ^{[1
]}

Naito, Tomoyuki ^{[2
]}

Udagawa, Hibiki ^{[2
]}

Goto, Koichi ^{[2
]}

Miyawaki, Taichi ^{[3
]}

Mamesaya, Nobuaki ^{[3
]}

Nakashima, Kazuhisa ^{[3
]}

Kenmotsu, Hirotsugu ^{[3
]}

Shimokawaji, Tadasuke ^{[4
]}

Kato, Terufumi ^{[4
]}

Hakozaki, Taiki ^{[5
]}

Okuma, Yusuke ^{[5
]}

Nakamura, Masaki ^{[6
]}

Nakayama, Yuko ^{[7
]}

Watanabe, Hirokazu ^{[8
]}

Kusumoto, Masahiko ^{[8
]}

Ohe, Yuichiro ^{[1
]}

Horinouchi, Hidehito ^{[1
,9
]}

机构：

[1] Natl Canc Ctr, Dept Thorac Oncol, Tokyo, Japan

[2] Natl Canc Ctr Hosp East, Dept Thorac Oncol, Kashiwa, Japan

[3] Shizuoka Canc Ctr, Dept Thorac Oncol, Shizuoka, Japan

[4] Kanagawa Canc Ctr, Dept Thorac Oncol, Yokohama, Japan

[5] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Dept Thorac Oncol & Resp Med, Tokyo, Japan

[6] Natl Canc Ctr Hosp East, Dept Radiat Oncol, Kashiwa, Japan

[7] Natl Canc Ctr, Dept Radiat Oncol, Tokyo, Japan

[8] Natl Canc Ctr, Dept Diagnost Radiol, Tokyo, Japan

[9] Natl Canc Ctr, Dept Thorac Oncol, 5-1-1 Tsukiji,Chuo Ku, Tokyo 1040045, Japan

来源：

CANCER SCIENCE | 2023年 / 114卷 / 02期

关键词：

antineoplastic agent; carcinoma; immune checkpoint inhibitor; immunological; nivolumab; non-small-cell lung; radiation pneumonitis; INHIBITOR-RELATED PNEUMONITIS; DOCETAXEL; PEMBROLIZUMAB; RADIOTHERAPY; MECHANISMS;

D O I：

10.1111/cas.15621

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of previous thoracic radiation therapy as a risk factor of immune-related pneumonitis is unclear. Furthermore, some patients develop radiation recall pneumonitis, which is characterized by a radiation pneumonitis-like imaging pattern with consolidation progressing within a previous radiation field. In this multicenter retrospective study, we analyzed the relationship of previous thoracic radiation therapy with immune-related pneumonitis and the characteristics of radiation recall pneumonitis. The medical records of patients with non-small-cell lung cancer who had received nivolumab between December 2015 and March 2017 at five institutions were retrospectively reviewed. Incidence, imaging patterns, clinical course, and risk factors of immune-related pneumonitis and radiation recall pneumonitis were evaluated. A total of 669 patients were evaluated, and the incidences of all-grade and grade 3 or higher immune-related pneumonitis were 8.8% and 2.6%, respectively. The incidences of immune-related pneumonitis were 13.2% (34/257) and 6.1% (25/412) in patients with and those without previous thoracic radiation therapy, respectively. A history of previous thoracic radiation therapy was associated with immune-related pneumonitis (odds ratio, 2.11; 95% confidence interval, 1.21-3.69 in multivariate analysis). Among the patients with previous thoracic radiation therapy, 6.2% (16/257) showed radiation recall pattern. This study found an increased risk of nivolumab-induced immune-related pneumonitis associated with a history of thoracic radiation therapy. Radiation recall pattern was one of the major patterns of immune-related pneumonitis among the patients with previous thoracic radiation therapy. Incidence, risk factors, and clinical outcome of radiation recall pneumonitis were elucidated.

引用

页码：630 / 639

页数：10

共 20 条

[11]

Postow MA, 2018, NEW ENGL J MED, V378, P158, DOI [10.1056/NEJMra1703481, 10.1056/NEJMc1801663]

[12] Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer [J].

Reck, Martin ;

Rodriguez-Abreu, Delvys ;

Robinson, Andrew G. ;

Hui, Rina ;

Csoszi, Tibor ;

Fulop, Andrea ;

Gottfried, Maya ;

Peled, Nir ;

Tafreshi, Ali ;

Cuffe, Sinead ;

O'Brien, Mary ;

Rao, Suman ;

Hotta, Katsuyuki ;

Leiby, Melanie A. ;

Lubiniecki, Gregory M. ;

Shentu, Yue ;

Rangwala, Reshma ;

Brahmer, Julie R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (19) :1823-1833

[13] Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial [J].

Rittmeyer, Achim ;

Barlesi, Fabrice ;

Waterkamp, Daniel ;

Park, Keunchil ;

Ciardiello, Fortunato ;

von Pawel, Joachim ;

Gadgeel, Shirish M. ;

Hida, Toyoaki ;

Kowalski, Dariusz M. ;

Dols, Manuel Cobo ;

Cortinovis, Diego L. ;

Leach, Joseph ;

Polikoff, Jonathan ;

Barrios, Carlos ;

Kabbinavar, Fairooz ;

Frontera, Osvaldo Aren ;

De Marinis, Filippo ;

Turna, Hande ;

Lee, Jong-Seok ;

Ballinger, Marcus ;

Kowanetz, Marcin ;

He, Pei ;

Chen, Daniel S. ;

Sandler, Alan ;

Gandara, David R. .

LANCET, 2017, 389 (10066) :255-265

[14] Treatment and relapse of interstitial lung disease in nivolumab-treated patients with non-small cell lung cancer [J].

Sata, Masafumi ;

Sasaki, Shinichi ;

Oikado, Katsunori ;

Saito, Yoshinobu ;

Tominaga, Junya ;

Sakai, Fumikazu ;

Kato, Terufumi ;

Iwasawa, Tae ;

Kenmotsu, Hirotsugu ;

Kusumoto, Masahiko ;

Baba, Tomohisa ;

Endo, Masahiro ;

Fujiwara, Yutaka ;

Sugiura, Hiroaki ;

Yanagawa, Noriyo ;

Ito, Yoshihiko ;

Sakamoto, Takahiko ;

Ohe, Yuichiro ;

Kuwano, Kazuyoshi .

CANCER SCIENCE, 2021, 112 (04) :1506-1513

[15] Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy [J].

Sharabi, Andrew B. ;

Lim, Michael ;

DeWeese, Theodore L. ;

Drake, Charles G. .

LANCET ONCOLOGY, 2015, 16 (13) :E498-E509

[16] Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial [J].

Shaverdian, Narek ;

Lisberg, Aaron E. ;

Bornazyan, Krikor ;

Veruttipong, Darlene ;

Goldman, Jonathan W. ;

Formenti, Silvia C. ;

Garon, Edward B. ;

Lee, Percy .

LANCET ONCOLOGY, 2017, 18 (07) :895-903

[17] Nivolumab induced radiation recall pneumonitis after two years of radiotherapy [J].

Shibaki, R. ;

Akamatsu, H. ;

Fujimoto, M. ;

Koh, Y. ;

Yamamoto, N. .

ANNALS OF ONCOLOGY, 2017, 28 (06) :1404-1405

[18] Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC [J].

Socinski, M. A. ;

Jotte, R. M. ;

Cappuzzo, F. ;

Orlandi, F. ;

Stroyakovskiy, D. ;

Nogami, N. ;

Rodriguez-Abreu, D. ;

Moro-Sibilot, D. ;

Thomas, C. A. ;

Barlesi, F. ;

Finley, G. ;

Kelsch, C. ;

Lee, A. ;

Coleman, S. ;

Deng, Y. ;

Shen, Y. ;

Kowanetz, M. ;

Lopez-Chavez, A. ;

Sandler, A. ;

Reck, M. ;

Ahualli, A. ;

Jarchum, G. ;

Kaen, D. L. ;

Kahl, S. ;

Kotliar, M. ;

Kowalyszyn, R. D. ;

Lerzo, G. ;

Magri, I ;

Martin, C. ;

Pastor, A. ;

Picon, P. ;

Streich, G. ;

Varela, M. ;

Blinman, P. ;

Boyer, M. ;

Crombie, C. ;

Gauden, S. ;

Gill, S. ;

Hughes, B. ;

John, T. ;

Joshi, A. ;

Kosmider, S. ;

Lewis, C. ;

Millward, M. ;

Nordman, I ;

Nott, L. ;

O'Byrne, K. ;

Parnis, F. ;

Potasz, N. ;

Richardson, G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (24) :2288-2301

[19] Pneumonitis in Non-Small Cell Lung Cancer Patients Receiving Immune Checkpoint Immunotherapy: Incidence and Risk Factors [J].

Suresh, Karthik ;

Khinh Ranh Voong ;

Shankar, Bairavi ;

Forde, Patrick M. ;

Ettinger, David S. ;

Marrone, Kristen A. ;

Kelly, Ronan J. ;

Hann, Christine L. ;

Levy, Benjamin ;

Feliciano, Josephine L. ;

Brahmer, Julie R. ;

Feller-Kopman, David ;

Lerner, Andrew D. ;

Lee, Hans ;

Yarmus, Lonny ;

D'Alessio, Franco ;

Hales, Russell K. ;

Lin, Cheng Ting ;

Psoter, Kevin J. ;

Danoff, Sonye K. ;

Naidoo, Jarushka .

JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (12) :1930-1939

[20] Relationship Between Prior Radiotherapy and Checkpoint-Inhibitor Pneumonitis in Patients With Advanced Non-Small-Cell Lung Cancer [J].

Voong, Khinh Ranh ;

Hazell, Sarah Z. ;

Fu, Wei ;

Hu, Chen ;

Lin, Cheng Ting ;

Ding, Kai ;

Suresh, Karthik ;

Hayman, Jonathan ;

Hales, Russell K. ;

Alfaifi, Salem ;

Marrone, Kristen A. ;

Levy, Benjamin ;

Hann, Christine L. ;

Ettinger, David S. ;

Feliciano, Josephine L. ;

Peterson, Valerie ;

Kelly, Ronan J. ;

Brahmer, Julie R. ;

Forde, Patrick M. ;

Naidoo, Jarushka .

CLINICAL LUNG CANCER, 2019, 20 (04) :E470-E479

← 1 2 →