Distinct antiviral activities of IFNI:p1 and IFNI:p4 in zebrafish

被引：4

作者：

Chen, Kangyong ^{[1
,2
,3
]}

Tian, Jiayin ^{[1
,2
,3
]}

Shi, Yanjie ^{[1
,2
,3
]}

Xie, Teng ^{[1
,2
,3
]}

Huang, Wenji ^{[1
,2
,3
]}

Jia, Zhao ^{[1
,2
,3
]}

Zhang, Yanwei ^{[1
,2
,3
]}

Yuan, Gaoliang ^{[1
,2
,3
]}

Yan, Hui ^{[1
,2
,3
]}

Wang, Junya ^{[1
,2
,3
]}

Zou, Jun ^{[1
,2
,3
,4
]}

机构：

[1] Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China

[2] Shanghai Ocean Univ, Int Res Ctr Marine Biosci, Minist Sci & Technol, Shanghai 201306, Peoples R China

[3] Shanghai Ocean Univ, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai 201306, Peoples R China

[4] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266200, Peoples R China

来源：

FISH & SHELLFISH IMMUNOLOGY | 2024年 / 146卷

关键词：

Zebrafish; Interferon; Virus; Antiviral response; I IFN; FUNCTIONAL-CHARACTERIZATION; INTERFERON GENES; IMMUNE-RESPONSE; PERCIFORM FISH; SHEDS LIGHT; EXPRESSION; STAT1; EVOLUTION; RECEPTOR;

D O I：

10.1016/j.fsi.2024.109396

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Interferons (IFNs) are a group of secreted cytokines that play a crucial role in antiviral immunity. Type I IFNs display functional disparities. In teleosts, type I IFNs are categorized into two subgroups containing one or two pairs of disulfide bonds. However, their functional differences have not been fully elucidated. In this study, we comparatively characterized the antiviral activities of zebrafish IFNI:p1 and IFNI:p4 belonging to the group I type I IFNs. It was found that ifn phi 1 and ifn phi 4 were differentially modulated during viral infection. Although both IFNI:p1 and IFNI:p4 activated JAK-STAT signaling pathway via CRFB1/CRFB5 receptor complex, IFNI:p4 was less potent in inducing phosphorylation of STAT1a, STAT1b and STAT2 and the expression of antiviral genes than IFNI:p1, thereby conferring weaker antiviral resistance of target cells. Taken together, our results provide insights into the functional divergence of type I IFNs in lower vertebrates.

引用

页数：11

共 49 条

[1] The Two Groups of Zebrafish Virus-Induced Interferons Signal via Distinct Receptors with Specific and Shared Chains [J].