Mutational Analysis in Mitochondrial Calcium Uniporter Gene from Patients with Alzheimer's disease

被引：0

作者：

Venugopal, Anila ^{[1
]}

Elangovan, Ajay ^{[1
]}

Babu, Harysh Winster Suresh ^{[1
]}

Sabari, Sri S. ^{[1
]}

Murali, Sanjana ^{[1
]}

Giridharan, Bupesh ^{[2
]}

Sidhic, Nihala ^{[1
]}

Das Talukdar, Ankur ^{[1
]}

Narayanaswamy, Arul ^{[3
]}

Vellingiri, Balachandar ^{[1
,4
]}

机构：

[1] Bharathiar Univ, Dept Human Genet & Mol Biol, Human Mol Cytogenet & Stem Cell Lab, Coimbatore 641046, Tamil Nadu, India

[2] Nagaland Univ, Dept Forest Sci, Nat Prod & its Cpd Res Lab, Zunheboto 798627, Nagaland, India

[3] Bharathiar Univ, Dept Human Genet & Mol Biol, Dis Prote Lab, Coimbatore 641046, Tamil Nadu, India

[4] Cent Univ Punjab, Sch Basic Sci, Dept Zool, Stem Cell & Regenerat Med,Translat Res, Bathinda 151401, Punjab, India

来源：

INTERNATIONAL JOURNAL OF HUMAN GENETICS | 2023年 / 23卷 / 2-3期

关键词：

Alzheimer's Disease; Comorbidities; Mitochondrial Calcium Uniporter; MICU1; Neurodegenerative; Socioeconomic; COMPLEX I; EPIGENETICS;

D O I：

10.31901/24566322.2023/23.2-3.851

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Due to population growth total number of people getting affected with Alzheimer's disease (AD) has dramatically increased. Unfortunately, there is no comprehensive analysis of diagnosis, progression, or treatment for AD in India. The chief study objective was to examine the risk factors associated with demographic and clinical features that could contribute to AD in India. A retrospective study was conducted with 174 AD patients with a structured questionnaire. It was observed by the researchers highly educated people from urban area are majorly diagnosed with AD. Cardiovascular diseases were found to be significant among the AD affected individuals. De novo point mutations were also identified among the participants. These findings indicate a necessity for proper diagnosis of AD and its follow-up care. It is essential to identify the demographic profile of AD in India to better the living conditions and ensure their proper treatment.

引用

页码：201 / 206

页数：6

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