Neural symphony of risky decision making in children with ADHD: Insights from transcranial alternating current stimulation and cognitive modeling

被引:3
作者
Nejati, Vahid [1 ,3 ]
Famininejad, Zahra [1 ]
Rad, Jamal Amani [2 ]
机构
[1] Shahid Beheshti Univ, Dept Psychol, Tehran, Iran
[2] Shahid Beheshti Univ, Inst Cognit & Brain Sci, Dept Cognit Modeling, Tehran, Iran
[3] Shahid Beheshti Univ, Dept Psychol, POB 1983969411, Tehran, Iran
来源
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY | 2023年 / 53卷 / 05期
关键词
Attention deficit-hyperactivity disorder (ADHD); Dorsolateral prefron-tal cortex (dlPFC); Ventromedial pre-frontal cortex (vmPFC); Risky decision making; Transcranial alternat-ing current stimula-tion (tACS); DEFICIT-HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; VENTROMEDIAL PREFRONTAL CORTEX; ORBITOFRONTAL CORTEX; EXECUTIVE FUNCTIONS; THETA; METAANALYSIS; TDCS; OSCILLATIONS; RECOGNITION;
D O I
10.1016/j.neucli.2023.102898
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: The ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC) are key brain regions involved in risky decision making, affected in individuals with attention deficit hyperactivity disorder (ADHD). This study aims to examine how entrainment of these areas impacts the process and outcome of risky decision making in children with ADHD.Methods: Eighteen children with ADHD performed the balloon analogue risk-taking task (BART) during five different sessions of tACS (1.5 mA, 6 Hz), separated by one-week intervals, via (1) two channels with synchronized stimulation over the left dlPFC and right vmPFC, (2) the same electrode placement with anti-phase stimulation, (3) stimulation over the left dlPFC only, (4) stimulation over right vmPFC only, and (5) sham stimulation. Four-parameter and constant sensitivity models were used to model the data.Results: The study showed that synchronized stimulation was associated with a reduction in positive prior belief, risk propensity, and deterministic selection. Desynchronized stimulation was associated with accelerated learning from initial selections. Isolated stimulation of the dlPFC leads to riskier decision enhanced learning updates and risk propensity, whereas isolated stimulation of the vmPFC facilitated faster learning and increased probabilistic selection.Conclusion: The results highlight the important roles of the dlPFC and vmPFC and their communication in decision making, showcasing their impact on various aspects of the decision-making process. The findings provide valuable insights into the complex interplay between cognitive and emotional factors in shaping our choices.& COPY; 2023 Elsevier Masson SAS. All rights reserved.
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页数:12
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