Tumor Markers and Their Diagnostic Significance in Ovarian Cancer

被引:24
作者
Matsas, Alkis [1 ]
Stefanoudakis, Dimitrios [2 ]
Troupis, Theodore [3 ]
Kontzoglou, Konstantinos [1 ]
Eleftheriades, Makarios [2 ]
Christopoulos, Panagiotis [2 ]
Panoskaltsis, Theodoros [2 ]
Stamoula, Eleni [4 ]
Iliopoulos, Dimitrios C. [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Med Sch, Lab Expt Surg & Surg Res NS Christeas, Athens 11527, Greece
[2] Natl & Kapodistrian Univ Athens, Aretaie Univ Hosp, Med Sch, Dept Obstet & Gynecol 2, Athens 11527, Greece
[3] Natl & Kapodistrian Univ Athens, Fac Hlth Sci, Med Sch, Dept Anat, MikrasAsias Str 75, Athens 11627, Greece
[4] Aristotle Univ Thessaloniki, Sch Med, Dept Clin Pharmacol, Univ Campus Aristotle Univ Thessaloniki, Thessaloniki 54124, Greece
来源
LIFE-BASEL | 2023年 / 13卷 / 08期
关键词
ovarian cancer; cancer biomarkers; early detection; prognosis; cancer diagnosis; CA-125; CA; 15-3; 19-9; HE4; hCG; inhibin; AFP; LDH; precision oncology; INDEPENDENT PROGNOSTIC-FACTOR; CELL-FREE DNA; PERITONEAL-FLUID; CA; 125; CLINICAL-SIGNIFICANCE; SERUM; CA125; MICRORNAS; HE-4; METHYLATION;
D O I
10.3390/life13081689
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ovarian cancer (OC) is characterized by silent progression and late-stage diagnosis. It is critical to detect and accurately diagnose the disease early to improve survival rates. Tumor markers have emerged as valuable tools in the diagnosis and management of OC, offering non-invasive and cost-effective options for screening, monitoring, and prognosis. Purpose: This paper explores the diagnostic importance of various tumor markers including CA-125, CA15-3, CA 19-9, HE4,hCG, inhibin, AFP, and LDH, and their impact on disease monitoring and treatment response assessment. Methods: Article searches were performed on PubMed, Scopus, and Google Scholar. Keywords used for the searching process were "Ovarian cancer", "Cancer biomarkers", "Early detection", "Cancer diagnosis", "CA-125","CA 15-3","CA 19-9", "HE4","hCG", "inhibin", "AFP", "LDH", and others. Results: HE4, when combined with CA-125, shows improved sensitivity and specificity, particularly in early-stage detection. Additionally, hCG holds promise as a prognostic marker, aiding treatment response prediction and outcome assessment. Novel markers like microRNAs, DNA methylation patterns, and circulating tumor cells offer potential for enhanced diagnostic accuracy and personalized management. Integrating these markers into a comprehensive panel may improve sensitivity and specificity in ovarian cancer diagnosis. However, careful interpretation of tumor marker results is necessary, considering factors such as age, menopausal status, and comorbidities. Further research is needed to validate and refine diagnostic algorithms, optimizing the clinical significance of tumor markers in ovarian cancer management. In conclusion, tumor markers such as CA-125, CA15-3, CA 19-9, HE4, and hCG provide valuable insights into ovarian cancer diagnosis, monitoring, and prognosis, with the potential to enhance early detection.
引用
收藏
页数:18
相关论文
共 50 条
[21]   RETRACTED: Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer (Retracted Article) [J].
Taylor, Douglas D. ;
Gercel-Taylor, Cicek ;
Parker, Lynn P. .
GYNECOLOGIC ONCOLOGY, 2009, 115 (01) :112-120
[22]   Clinical significance of blood-based miRNAs as diagnostic and prognostic nucleic acid markers in breast cancer: Comparative to conventional tumor markers [J].
Swellam, Menha ;
Ramadan, Amal ;
El-Hussieny, Enas A. ;
Bakr, Noha M. ;
Hassan, Naglaa M. ;
Sobeih, Mohamed Emam ;
EzzElArab, Lobna R. .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (08) :12321-12330
[23]   Early Detection of Ovarian Cancer [J].
Elias, Kevin M. ;
Guo, Jing ;
Bast, Robert C., Jr. .
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2018, 32 (06) :903-+
[24]   Liquid biopsy in ovarian cancer [J].
Bhardwaj, Boddapati Kalyani ;
Thankachan, Sanu ;
Venkatesh, Thejaswini ;
Suresh, Padmanaban S. .
CLINICA CHIMICA ACTA, 2020, 510 :28-34
[25]   The Role of Circulating Tumor DNA in Ovarian Cancer [J].
Golara, Anna ;
Kozlowski, Mateusz ;
Cymbaluk-Ploska, Aneta .
CANCERS, 2024, 16 (18)
[26]   TOWARD AN OPTIMAL ALGORITHM FOR OVARIAN-CANCER SCREENING WITH LONGITUDINAL TUMOR-MARKERS [J].
SKATES, SJ ;
XU, FJ ;
YU, YH ;
SJOVALL, K ;
EINHORN, N ;
CHANG, YC ;
BAST, RC ;
KNAPP, RC .
CANCER, 1995, 76 (10) :2004-2010
[27]   Diagnostic and prognostic role of circulating neutrophil extracellular trap markers and prekallikrein in patients with high-grade serous ovarian cancer [J].
Kim, Jisoo ;
Kim, Se Ik ;
Song, Sang Hoon ;
Gu, Ja-Yoon ;
Lee, Maria ;
Kim, Hyun Kyung .
FRONTIERS IN ONCOLOGY, 2022, 12
[28]   Serum anti-CFL1, anti-EZR, and anti-CYPA autoantibody as diagnostic markers in ovarian cancer [J].
Cheng, Yifan ;
Li, Qing ;
Sun, Guiying ;
Li, Tiandong ;
Zou, Yuanlin ;
Ye, Hua ;
Wang, Keyan ;
Shi, Jianxiang ;
Wang, Peng .
SCIENTIFIC REPORTS, 2024, 14 (01)
[29]   Identification of circulating microRNAs as diagnostic biomarkers for ovarian cancer: A pooled analysis of individual studies [J].
Zhou, Quan ;
Zuo, Man-Zhen ;
He, Ze ;
Li, Hai-Rong ;
Li, Wei .
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 2018, 33 (04) :379-388
[30]   The Prognostic Value of Circulating Tumor DNA in Ovarian Cancer: A Meta-Analysis [J].
Lu, Yuanyuan ;
Li, Li .
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2021, 20