Aggregation-induced emission biomaterials for anti-pathogen medical applications: detecting, imaging and killing

被引：14
作者：
Zhang, Zicong [1 ]
Deng, Ziwei [1 ]
Zhu, Lixun [1 ]
Zeng, Jialin [1 ]
Cai, Xu Min [2 ]
Qiu, Zijie [1 ]
Zhao, Zheng [1 ,3 ]
Tang, Ben Zhong [1 ,4 ]
机构：
[1] Chinese Univ Hong Kong, Affiliated Hosp 2, Clin Translat Res Ctr Aggregat Induced Emiss, Sch Med, Shenzhen 518172, Guangdong, Peoples R China
[2] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Peoples R China
[3] HKUST, Shenzhen Res Inst, South Area Hitech Pk,Nanshan, Shenzhen 518057, Guangdong, Peoples R China
[4] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem, Hong Kong Branch, Clear Water Bay, Hong Kong, Peoples R China
来源：
REGENERATIVE BIOMATERIALS | 2023年 / 10卷
关键词：
aggregation-induced emission; fluorescence imaging; pathogen differentiation; pathogen inactivation; MOLECULAR DIAGNOSTICS; DIRECT VISUALIZATION; FLUORESCENT; DESIGN; VIABILITY; AIEGEN; PROBE; DISCRIMINATION; THERANOSTICS; ANTIBIOTICS;
D O I：
10.1093/rb/rbad044
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Microbial pathogens, including bacteria, fungi and viruses, greatly threaten the global public health. For pathogen infections, early diagnosis and precise treatment are essential to cut the mortality rate. The emergence of aggregation-induced emission (AIE) biomaterials provides an effective and promising tool for the theranostics of pathogen infections. In this review, the recent advances about AIE biomaterials for anti-pathogen theranostics are summarized. With the excellent sensitivity and photostability, AIE biomaterials have been widely applied for precise diagnosis of pathogens. Besides, different types of anti-pathogen methods based on AIE biomaterials will be presented in detail, including chemotherapy and phototherapy. Finally, the existing deficiencies and future development of AIE biomaterials for anti-pathogen applications will be discussed.
引用
收藏
页数：18
相关论文
共 122 条
  • [81] Molecular diagnostics for the detection and characterization of microbial pathogens
    Procop, Gary W.
    [J]. CLINICAL INFECTIOUS DISEASES, 2007, 45 : S99 - S111
  • [82] AIE Luminogens for Bioimaging and Theranostics: from Organelles to Animals
    Qian, Jun
    Tang, Ben Zhong
    [J]. CHEM, 2017, 3 (01): : 56 - 91
  • [83] Organic Photo-antimicrobials: Principles, Molecule Design, and Applications
    Ran, Bei
    Wang, Zuokai
    Cai, Wenlin
    Ran, Lei
    Xia, Wenxi
    Liu, Weijian
    Peng, Xiaojun
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 143 (43) : 17891 - 17909
  • [84] Antifungal susceptibility testing: Practical aspects and current challenges
    Rex, JH
    Pfaller, MA
    Walsh, TJ
    Chaturvedi, V
    Espinel-Ingroff, A
    Ghannoum, MA
    Gosey, LL
    Odds, FC
    Rinaldi, MG
    Sheehan, DJ
    Warnock, DW
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (04) : 643 - 658
  • [85] Diagnosis and treatment of invasive fungal infections: looking ahead
    Sanguinetti, Maurizio
    Posteraro, Brunella
    Beigelman-Aubry, Catherine
    Lamoth, Frederic
    Dunet, Vincent
    Slavin, Monica
    Richardson, Malcolm D.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019, 74 : 27 - 37
  • [86] A dibenzothiophene core-based small-molecule AIE probe for wash-free and selective staining of lipid droplets in live mammalian and fungal cells
    Sayed, Sayed Mir
    Li, Xiang-Fei
    Jia, Hao-Ran
    Durrani, Samran
    Wu, Fu-Gen
    Lu, Xiaolin
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 2021, 343
  • [87] Killing G(+) or G(-) Bacteria? The Important Role of Molecular Charge in AIE-Active Photosensitizers
    Shi, Xiujuan
    Sung, Simon H. P.
    Chau, Joe H. C.
    Li, Ying
    Liu, Zhiyang
    Kwok, Ryan T. K.
    Liu, Junkai
    Xiao, Peihong
    Zhang, Jiangjiang
    Liu, Bin
    Lam, Jacky W. Y.
    Tang, Ben Zhong
    [J]. SMALL METHODS, 2020, 4 (07)
  • [88] The Bacterial Cell Envelope
    Silhavy, Thomas J.
    Kahne, Daniel
    Walker, Suzanne
    [J]. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (05): : a000414
  • [89] Singh S. B., 2014, J. Energy Eng, V2, P106, DOI DOI 10.1016/J.JSCS.2011.01.015
  • [90] Smith PL, 1998, CLIN CHEM, V44, P2054
45678910111213