Aggregation-induced emission biomaterials for anti-pathogen medical applications: detecting, imaging and killing

被引：14
作者：
Zhang, Zicong [1 ]
Deng, Ziwei [1 ]
Zhu, Lixun [1 ]
Zeng, Jialin [1 ]
Cai, Xu Min [2 ]
Qiu, Zijie [1 ]
Zhao, Zheng [1 ,3 ]
Tang, Ben Zhong [1 ,4 ]
机构：
[1] Chinese Univ Hong Kong, Affiliated Hosp 2, Clin Translat Res Ctr Aggregat Induced Emiss, Sch Med, Shenzhen 518172, Guangdong, Peoples R China
[2] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Peoples R China
[3] HKUST, Shenzhen Res Inst, South Area Hitech Pk,Nanshan, Shenzhen 518057, Guangdong, Peoples R China
[4] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem, Hong Kong Branch, Clear Water Bay, Hong Kong, Peoples R China
来源：
REGENERATIVE BIOMATERIALS | 2023年 / 10卷
关键词：
aggregation-induced emission; fluorescence imaging; pathogen differentiation; pathogen inactivation; MOLECULAR DIAGNOSTICS; DIRECT VISUALIZATION; FLUORESCENT; DESIGN; VIABILITY; AIEGEN; PROBE; DISCRIMINATION; THERANOSTICS; ANTIBIOTICS;
D O I：
10.1093/rb/rbad044
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Microbial pathogens, including bacteria, fungi and viruses, greatly threaten the global public health. For pathogen infections, early diagnosis and precise treatment are essential to cut the mortality rate. The emergence of aggregation-induced emission (AIE) biomaterials provides an effective and promising tool for the theranostics of pathogen infections. In this review, the recent advances about AIE biomaterials for anti-pathogen theranostics are summarized. With the excellent sensitivity and photostability, AIE biomaterials have been widely applied for precise diagnosis of pathogens. Besides, different types of anti-pathogen methods based on AIE biomaterials will be presented in detail, including chemotherapy and phototherapy. Finally, the existing deficiencies and future development of AIE biomaterials for anti-pathogen applications will be discussed.
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页数：18
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