DNA methylation dynamics during pregnancy

被引：5

作者：

Fradin, Delphine ^{[1
,6
]}

Tost, Jorg ^{[2
]}

Busato, Florence ^{[2
]}

Mille, Clemence ^{[1
]}

Lachaux, Fanny ^{[1
]}

Deleuze, Jean-Francois ^{[3
]}

Apter, Gisele ^{[4
]}

Benachi, Alexandra ^{[5
]}

机构：

[1] Paris Sud Univ, Bicetre Hosp, INSERM, U1169, Paris, France

[2] Univ Paris Saclay, CEA Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine, Lab Epigenet & Environm, Evry, France

[3] Univ Paris Saclay, Inst Biol Francois Jacob, Ctr Natl Rech Genom Humaine, CEA, Evry, France

[4] Univ Rouen Normandie, Le Havre Univ Hosp, Child & Perinatal Psychiat Dept, Le Havre, France

[5] Univ Paris Saclay, Antoine Beclere Hosp, AP HP, Dept Obstet & Gynecol,DMU Sante Femmes & Nouveaune, Paris, France

[6] Univ Angers, Nantes Univ, CNRS, INSERM,UMR 1307,UMR 6075,CRCI2NA, Nantes, France

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

关键词：

DNA methylation; pregnancy; changes; bonding; immunity; BODY-MASS INDEX; EPIGENOME-WIDE;

D O I：

10.3389/fcell.2023.1185311

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pregnancy is a state of multiple physiological adaptations. Since methylation of DNA is an epigenetic mechanism that regulates gene expression and contributes to adaptive phenotypic variations, we investigated methylation changes in maternal blood of a longitudinal cohort of pregnant women from the first trimester of gestation to the third. Interestingly, during pregnancy, we found a gain of methylation in genes involved in morphogenesis, such as ezrin, while we identified a loss of methylation in genes promoting maternal-infant bonding (AVP and PPP1R1B). Together, our results provide insights into the biological mechanisms underlying physiological adaptations during pregnancy.

引用

页数：5

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