High fish intake rich in n-3 polyunsaturated fatty acids reduces cardiovascular disease incidence in healthy adults: The ATTICA cohort study (2002-2022)

被引：7

作者：

Critselis, Elena ^{[1
,2
]}

Tsiampalis, Thomas ^{[1
]}

Damigou, Evangelia ^{[1
]}

Georgousopoulou, Ekavi ^{[3
]}

Barkas, Fotios ^{[1
]}

Chrysohoou, Christina ^{[4
]}

Skoumas, John ^{[4
]}

Pitsavos, Christos ^{[4
]}

Liberopoulos, Evangelos ^{[5
]}

Tsioufis, Costas ^{[4
]}

Sfikakis, Petros P. ^{[5
]}

Panagiotakos, Demosthenes ^{[1
,3
]}

机构：

[1] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece

[2] Univ Nicosia, Med Sch, Dept Primary Care & Populat Hlth, Nicosia, Cyprus

[3] Univ Canberra, Fac Hlth, Discipline Nutr & Dietet, Canberra, ACT, Australia

[4] Natl & Kapodistrian Univ Athens, Sch Med, Cardiol Clin 1, Athens, Greece

[5] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Sch Med, Dept Propaedeut Internal Med 1, Athens, Greece

来源：

FRONTIERS IN PHYSIOLOGY | 2023年 / 14卷

关键词：

mediterranean diet; nutrition; fish; fish oils; omega-3 fatty acids; cardiovascular disease; incidence; mortality; ALL-CAUSE MORTALITY; OIL SUPPLEMENTATION; PHYSICAL-ACTIVITY; RISK-FACTORS; CONSUMPTION; PREVENTION; PREVALENCE; GUIDELINES; PATTERNS; MARKERS;

D O I：

10.3389/fphys.2023.1158140

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Background: The long-term effects of high fish intake rich in n-3 fatty acids for deterring cardiovascular disease (CVD) and related adverse outcomes in healthy individuals have not been yet elucidated.Purpose: To evaluate the association between total seafood, as well as small fish, intake on 10- and 20-year CVD incidence and mortality in healthy adults.Methods: A prospective cohort study (n = 2,020) was conducted in healthy community dwelling adults in Athens, Greece, selected following age- and sex-based random multistage sampling (mean +/- SD age at baseline: 45.2 +/- 14.0 years). Seafood (high (>2 servings/week) vs. low (<= 2 servings/week) intake), including small fish rich in n-3 fatty acids (high (>1 serving/week) vs. low (<= 1 serving/week) intake), consumption was evaluated by semi-quantitative food frequency questionnaire at baseline. The occurrence of non-fatal and/or fatal CVD events (ICD-10) was assessed during 10- and 20-year follow-up periods.Results: Only 32.7% and 9.6% of participants had high seafood and small fish intakes, respectively. Participants with high seafood intake had 27% decreased 10-year CVD risk (adj. HR:0.73; 95% CI:0.55-0.98) and 74% lower attributable mortality (adj. HR:0.26; 95% CI:0.11-0.58). Participants with high seafood intake also sustained a 24% lower 20-year risk of CVD mortality (adj. HR: 0.76; 95% CI: 0.55-0.98). Moreover, participants with high small fish intake had a lower 10-year CVD risk and 76% decreased risk of 10-year CVD mortality (adj. HR:0.24; 95% CI:0.06-0.99), even among normotensive individuals (adj. HR:0.31; 95% CI:0.13-0.73). When analogous analyses focused on 20-year CVD incidence and mortality, similar but not significant associations were observed (all p-values >0.10).Conclusion: High intake of seafood, and particularly small fish rich in n-3 fatty acids, was associated with a lower risk of 10-year fatal and non-fatal CVD. Thus, public health interventions aimed at enhancing small fish consumption may most effectively deter long-term CVD outcomes, particularly among low risk normotensive individuals.

引用

页数：11

共 44 条

[1] Molecular and biological hallmarks of ageing [J].