Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort

被引:8
作者
Chen, Zhaofeng [1 ,2 ]
Zheng, Ya [1 ,2 ]
Fan, Ping [3 ]
Li, Min [4 ]
Liu, Wei [4 ]
Yuan, Hao [1 ,2 ]
Liu, Xin [5 ]
Zhang, Zhiyi [3 ]
Wu, Zhengqi [3 ]
Wang, Yuping [1 ,2 ]
Ji, Rui [1 ,2 ]
Guo, Qinghong [1 ,2 ]
Ye, Yuwei [1 ,2 ]
Zhang, Jinhua [6 ]
Li, Xiaohua [7 ]
An, Feng [8 ]
Lu, Linzhi [3 ]
Li, Youpeng [9 ]
Wang, Xiang [10 ]
Zhang, Jun [1 ,2 ]
Guan, Quanlin [11 ]
Li, Qiang [1 ,2 ]
Liu, Min [1 ,2 ]
Ren, Qian [1 ,2 ]
Hu, Xiaobin [12 ]
Lu, Hong [1 ,2 ]
Zhang, Hongling [1 ,2 ]
Zhao, Yue [1 ,2 ]
Gou, Xi [1 ,2 ]
Shu, Xiaochuang [1 ,2 ]
Wang, Jun [1 ,2 ]
Hu, Zenan [1 ,2 ]
Xue, Siqian [13 ]
Liu, Jiankang [14 ]
Zhou, Yongning [1 ,2 ]
机构
[1] Lanzhou Univ, Dept Gastroenterol, Hosp 1, Lanzhou, Gansu, Peoples R China
[2] Lanzhou Univ, Key Lab Gastrointestinal Dis Gansu Prov, Hosp 1, Lanzhou, Gansu, Peoples R China
[3] Gansu Wuwei Tumor Hosp, Wuwei, Gansu, Peoples R China
[4] Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China
[5] 940 Hosp Joint Serv Logist Support Force Chinese P, Dept Gastroenterol, Lanzhou, Gansu, Peoples R China
[6] Gansu Second Prov Peoples Hosp, Lanzhou, Gansu, Peoples R China
[7] Wuwei Liangzhou Hosp, Wuwei, Gansu, Peoples R China
[8] Wuwei Peoples Hosp, Wuwei, Gansu, Peoples R China
[9] Minqin Peoples Hosp, Minqin, Gansu, Peoples R China
[10] Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China
[11] Lanzhou Univ, Surg Oncol Dept, Hosp 1, Lanzhou, Gansu, Peoples R China
[12] Lanzhou Univ, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China
[13] Lanzhou Univ, Intervent Radiol Dept, Hosp 1, Lanzhou, Gansu, Peoples R China
[14] Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA USA
关键词
Helicobacter pylori; gastric adenocarcinoma; premalignant lesions; risk factors; progression; HELICOBACTER-PYLORI ERADICATION; INTESTINAL METAPLASIA; ALCOHOL-DRINKING; CANCER INCIDENCE; GANSU PROVINCE; METAANALYSIS; ESOPHAGEAL; MANAGEMENT; MORTALITY; CHINA;
D O I
10.3389/fmicb.2022.1024155
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Several risk factors have been identified for the development of gastric adenocarcinoma (GAC), where the control group was usually a healthy population. However, it is unclear at what stage known risk factor exert their influence toward the progression to cancer. Based on the Wuwei Cohort, we enrolled 1,739 patients with chronic non-atrophic gastritis (no-CAG), 3,409 patients with chronic atrophic gastritis (CAG), 1,757 patients with intestinal metaplasia (IM), 2,239 patients with low-grade dysplasia (LGD), and 182 patients with high-grade dysplasia (HGD) or GAC to assess the risk factors between each two consecutive stages from no-CAG to GAC/HGD using adjusted logistic regression. We found that different groups of risk factors were associated with different stages. Age, occupation of farmer, low annual family income, Helicobacter pylori (H. pylori) infection, drinking, eating hot food, histories of gastritis and peptic ulcer were associated with the development of CAG. Age, illiteracy, H. pylori infection, smoking, eating hot food, eating quickly, and histories of gastritis and gallbladder diseases were associated with the progression to IM from CAG. Male, occupation of farmer and history of peptic ulcer were associated with the development of LGD from IM. Age, male and polyp history appeared to be risk factors associated with the development of GAC/HGD from LGD. In conclusion, it seems that most risk factors function more as a set of switches that initiated the GAC carcinogenesis. H. Pylori eradication and control of other risk factors should be conducted before IM to decrease the incidence of GAC.
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页数:10
相关论文
共 44 条
[11]  
Fred TB., 2010, World Health Organization Classification of tumors, V4th
[12]   Reversibility of atrophic gastritis and intestinal metaplasia after Helicobacter pylori eradication - a prospective study for up to 10 years [J].
Hwang, Y. -J. ;
Kim, N. ;
Lee, H. S. ;
Lee, J. B. ;
Choi, Y. J. ;
Yoon, H. ;
Shin, C. M. ;
Park, Y. S. ;
Lee, D. H. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2018, 47 (03) :380-390
[13]  
Jemal A, 2011, CA-CANCER J CLIN, V61, P134, DOI [10.3322/caac.20107, 10.3322/caac.21492, 10.3322/caac.20115]
[14]   Socio-economic and occupational risk factors for gastric cancer: a cohort study in Sweden [J].
Ji, Jianguang ;
Hemminki, Kari .
EUROPEAN JOURNAL OF CANCER PREVENTION, 2006, 15 (05) :391-397
[15]   Cohort Profile: A population-based cohort for the study of gastric cancer in northwest area of China (Wuwei Cohort) [J].
Ji, Rui ;
Zhang, Zhiyi ;
Zhang, Jinhua ;
Wu, Zhengqi ;
Li, Min ;
Ye, Yuwei ;
Li, Xiaohua ;
An, Feng ;
Xu, Chuanggui ;
Lu, Linzhi ;
Fan, Ping ;
Chen, Zhaofeng ;
Guo, Qinghong ;
Wang, Yuping ;
Wang, Xiang ;
Li, Youpeng ;
Zhang, Jun ;
Guan, Quanlin ;
Hu, Xiaobin ;
Yang, Tianlin ;
Liu, Jiankang ;
Qiao, Liang ;
Zheng, Ya ;
Zhou, Yongning .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2021, 50 (05) :1433-+
[16]  
Kang Sung Hwa, 2017, Ann Hepatobiliary Pancreat Surg, V21, P131, DOI 10.14701/ahbps.2017.21.3.131
[17]  
Kato I, 2004, CANCER EPIDEM BIOMAR, V13, P468
[18]  
Kim K, 2019, CANCER RES, V79, P676, DOI [10.1158/0008-5472.CAN-18-2268, 10.1158/0008-5472.can-18-2268]
[19]   Chemoprevention of gastric cancer by Helicobacter pylori eradication and its underlying mechanism [J].
Kim, Nayoung .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2019, 34 (08) :1287-1295
[20]   Endoscopic surveillance of gastric cancers after Helicobacter pylori eradication [J].
Kobayashi, Masaaki ;
Sato, Yuichi ;
Terai, Shuji .
WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (37) :10553-10562