Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort

被引:8
作者
Chen, Zhaofeng [1 ,2 ]
Zheng, Ya [1 ,2 ]
Fan, Ping [3 ]
Li, Min [4 ]
Liu, Wei [4 ]
Yuan, Hao [1 ,2 ]
Liu, Xin [5 ]
Zhang, Zhiyi [3 ]
Wu, Zhengqi [3 ]
Wang, Yuping [1 ,2 ]
Ji, Rui [1 ,2 ]
Guo, Qinghong [1 ,2 ]
Ye, Yuwei [1 ,2 ]
Zhang, Jinhua [6 ]
Li, Xiaohua [7 ]
An, Feng [8 ]
Lu, Linzhi [3 ]
Li, Youpeng [9 ]
Wang, Xiang [10 ]
Zhang, Jun [1 ,2 ]
Guan, Quanlin [11 ]
Li, Qiang [1 ,2 ]
Liu, Min [1 ,2 ]
Ren, Qian [1 ,2 ]
Hu, Xiaobin [12 ]
Lu, Hong [1 ,2 ]
Zhang, Hongling [1 ,2 ]
Zhao, Yue [1 ,2 ]
Gou, Xi [1 ,2 ]
Shu, Xiaochuang [1 ,2 ]
Wang, Jun [1 ,2 ]
Hu, Zenan [1 ,2 ]
Xue, Siqian [13 ]
Liu, Jiankang [14 ]
Zhou, Yongning [1 ,2 ]
机构
[1] Lanzhou Univ, Dept Gastroenterol, Hosp 1, Lanzhou, Gansu, Peoples R China
[2] Lanzhou Univ, Key Lab Gastrointestinal Dis Gansu Prov, Hosp 1, Lanzhou, Gansu, Peoples R China
[3] Gansu Wuwei Tumor Hosp, Wuwei, Gansu, Peoples R China
[4] Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China
[5] 940 Hosp Joint Serv Logist Support Force Chinese P, Dept Gastroenterol, Lanzhou, Gansu, Peoples R China
[6] Gansu Second Prov Peoples Hosp, Lanzhou, Gansu, Peoples R China
[7] Wuwei Liangzhou Hosp, Wuwei, Gansu, Peoples R China
[8] Wuwei Peoples Hosp, Wuwei, Gansu, Peoples R China
[9] Minqin Peoples Hosp, Minqin, Gansu, Peoples R China
[10] Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China
[11] Lanzhou Univ, Surg Oncol Dept, Hosp 1, Lanzhou, Gansu, Peoples R China
[12] Lanzhou Univ, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China
[13] Lanzhou Univ, Intervent Radiol Dept, Hosp 1, Lanzhou, Gansu, Peoples R China
[14] Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA USA
关键词
Helicobacter pylori; gastric adenocarcinoma; premalignant lesions; risk factors; progression; HELICOBACTER-PYLORI ERADICATION; INTESTINAL METAPLASIA; ALCOHOL-DRINKING; CANCER INCIDENCE; GANSU PROVINCE; METAANALYSIS; ESOPHAGEAL; MANAGEMENT; MORTALITY; CHINA;
D O I
10.3389/fmicb.2022.1024155
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Several risk factors have been identified for the development of gastric adenocarcinoma (GAC), where the control group was usually a healthy population. However, it is unclear at what stage known risk factor exert their influence toward the progression to cancer. Based on the Wuwei Cohort, we enrolled 1,739 patients with chronic non-atrophic gastritis (no-CAG), 3,409 patients with chronic atrophic gastritis (CAG), 1,757 patients with intestinal metaplasia (IM), 2,239 patients with low-grade dysplasia (LGD), and 182 patients with high-grade dysplasia (HGD) or GAC to assess the risk factors between each two consecutive stages from no-CAG to GAC/HGD using adjusted logistic regression. We found that different groups of risk factors were associated with different stages. Age, occupation of farmer, low annual family income, Helicobacter pylori (H. pylori) infection, drinking, eating hot food, histories of gastritis and peptic ulcer were associated with the development of CAG. Age, illiteracy, H. pylori infection, smoking, eating hot food, eating quickly, and histories of gastritis and gallbladder diseases were associated with the progression to IM from CAG. Male, occupation of farmer and history of peptic ulcer were associated with the development of LGD from IM. Age, male and polyp history appeared to be risk factors associated with the development of GAC/HGD from LGD. In conclusion, it seems that most risk factors function more as a set of switches that initiated the GAC carcinogenesis. H. Pylori eradication and control of other risk factors should be conducted before IM to decrease the incidence of GAC.
引用
收藏
页数:10
相关论文
共 44 条
  • [1] The role of endoscopy in the management of patients with peptic ulcer disease
    Banerjee, Subhas
    Cash, Brooks D.
    dominitz, Jason A.
    Baron, Todd H.
    Anderson, Michelle A.
    Ben-Menachem, Tamir
    Fisher, Laurel
    Fukami, Norio
    Harrison, M. Edwyn
    Ikenberry, Steven O.
    Khan, Khalid
    Krinsky, Mary Lee
    Maple, John
    Fanelli, Robert D.
    Strohmeyer, Laura
    [J]. GASTROINTESTINAL ENDOSCOPY, 2010, 71 (04) : 663 - 668
  • [2] Gastric cancer pathogenesis
    Berger, Hilmar
    Marques, Miguel S.
    Zietlow, Rike
    Meyer, Thomas F.
    Machado, Jose C.
    Figueiredo, Ceu
    [J]. HELICOBACTER, 2016, 21 : 34 - 38
  • [3] Current Management of Benign Epithelial Gastric Polyps
    Antonio R. Cheesman
    David A. Greenwald
    Shailja C. Shah
    [J]. Current Treatment Options in Gastroenterology, 2017, 15 (4) : 676 - 690
  • [4] Cancer Statistics in China, 2015
    Chen, Wanqing
    Zheng, Rongshou
    Baade, Peter D.
    Zhang, Siwei
    Zeng, Hongmei
    Bray, Freddie
    Jemal, Ahmedin
    Yu, Xue Qin
    He, Jie
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2016, 66 (02) : 115 - 132
  • [5] Body Mass Index and Risk of Gastric Cancer: A Meta-analysis of a Population with More Than Ten Million from 24 Prospective Studies
    Chen, Yi
    Liu, Lingxiao
    Wang, Xiaolin
    Wang, Jianhua
    Yan, Zhiping
    Cheng, Jieming
    Gong, Gaoquan
    Li, Guoping
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2013, 22 (08) : 1395 - 1408
  • [6] CORREA P, 1992, CANCER RES, V52, P6735
  • [7] The gastric precancerous cascade
    Correa, Pelayo
    Piazuelo, M. Blanca
    [J]. JOURNAL OF DIGESTIVE DISEASES, 2012, 13 (01) : 2 - 9
  • [8] Oesophageal and gastric intestinal-type adenocarcinomas show the same male predominance due to a 17 year delayed development in females
    Derakhshan, M. H.
    Liptrot, S.
    Paul, J.
    Brown, I. L.
    Morrison, D.
    McColl, K. E. L.
    [J]. GUT, 2009, 58 (01) : 16 - 23
  • [9] Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
    Duell, Eric J.
    Travier, Noemie
    Lujan-Barroso, Leila
    Clavel-Chapelon, Francoise
    Boutron-Ruault, Marie-Christine
    Morois, Sophie
    Palli, Domenico
    Krogh, Vittorio
    Panico, Salvatore
    Tumino, Rosario
    Sacerdote, Carlotta
    Ramon Quiros, J.
    Sanchez-Cantalejo, Emilio
    Navarro, Carmen
    Barricarte Gurrea, Aurelio
    Dorronsoro, Miren
    Khaw, Kay-Tee
    Allen, Naomi E.
    Key, Timothy J.
    Bueno-de-Mesquita, H. Bas
    Ros, Martine M.
    Numans, Mattijs E.
    Peeters, Petra H. M.
    Trichopoulou, Antonia
    Naska, Androniki
    Dilis, Vardis
    Teucher, Birgit
    Kaaks, Rudolf
    Boeing, Heiner
    Schuetze, Madlen
    Regner, Sara
    Lindkvist, Bjoern
    Johansson, Ingegerd
    Hallmans, Goran
    Overvad, Kim
    Egeberg, Rikke
    Tjonneland, Anne
    Lund, Eiliv
    Weiderpass, Elisabete
    Braaten, Tonje
    Romieu, Isabelle
    Ferrari, Pietro
    Jenab, Mazda
    Stenling, Roger
    Aune, Dagfinn
    Norat, Teresa
    Riboli, Elio
    Gonzalez, Carlos A.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2011, 94 (05) : 1266 - 1275
  • [10] Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies
    Fang, Xuexian
    Wei, Jiayu
    He, Xuyan
    An, Peng
    Wang, Hao
    Jiang, Li
    Shao, Dandan
    Liang, Han
    Li, Yi
    Wang, Fudi
    Min, Junxia
    [J]. EUROPEAN JOURNAL OF CANCER, 2015, 51 (18) : 2820 - 2832