Asymmetric syntheses of ent-pimarane diterpenoids

被引：2

作者：

Li, Yunzhou ^{[1
]}

Fu, Shaomin ^{[1
]}

Liu, Bo ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 21期

关键词：

D O I：

10.1039/d3ob00575e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aromatic ent-pimaranes are a group of aromatized tricyclic diterpenoids that exhibit diverse bioactivities. In this work, the first total syntheses of two aromatic ent-pimaranes were achieved via a C-ABC construction sequence enabled by chiral auxiliary controlled asymmetric radical polyene cyclization, and the subsequent substrate-controlled stereo-/regio-specific hydroboration of alkene allowed for access to both natural products with C19 oxidation modifications.

引用

页码：4409 / 4413

页数：5

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