Asymmetric Palladium-Catalyzed Aminochlorination of Unactivated Alkenes

被引：8

作者：

Wang, Zhigang ^{[1
]}

Hou, Chuanqi ^{[1
,2
,3
]}

Chen, Pinhong ^{[1
,2
,3
]}

机构：

[1] Univ Shanghai Sci & Technol, Sch Mat & Chem, Shanghai 200093, Peoples R China

[2] Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth,Shanghai Hong Kong Joint, Shanghai 200032, Peoples R China

[3] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 15期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

INTRAMOLECULAR CHLOROAMINATION; STEREOSELECTIVE-SYNTHESIS; HALOGENATION; STRATEGIES; REACTIVITY; LIGANDS; OLEFIN;

D O I：

10.1021/acs.orglett.3c00771

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Pd-catalyzed enantioselective aminochlori-nation of alkenes via a 6-endo cyclization is reported herein, which provides easy access to a wide array of structurally diverse 3-chloropiperidines in good yields with excellent enantioselectivities. Notably, both an electrophilic chlorination reagent (NCS) and the sterically bulky chiral pyridinyl-oxazoline (Pyox) ligand are crucial to the successful reaction.

引用

页码：2685 / 2690

页数：6

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