Accuracy of automated analyzers for the estimation of CSF cell counts: A systematic review and meta-analysis

被引:1
|
作者
Waldrop, Greer E. [1 ]
Cocuzzo, Kaitlyn [1 ]
Schneider, Colleen L. [2 ]
Kim, Carla Y. [1 ]
Goetz, Teddy G. [1 ]
Chomba, Mashina S. [1 ,3 ,4 ]
Delaurentis, Clare E. [5 ]
Smithgall, Marie C. [6 ]
Francis, Richard O. [7 ]
Thakur, Kiran T. [1 ]
机构
[1] Columbia Univ, Irving Med Ctr, New York Presbyterian Hosp, Dept Neurol, 710 West 168th St, New York, NY 10032 USA
[2] Univ Rochester, Sch Med & Dent, Med Scientist Training Program, Rochester, NY USA
[3] Univ Teaching Hosp, Sch Med, Lusaka, Zambia
[4] Univ Zambia, Lusaka, Zambia
[5] Columbia Univ, Dept Infect Dis, Irving Med Ctr, New York, NY USA
[6] Weill Cornell Med, Dept Pathol, New York, NY USA
[7] Columbia Univ, Vagelos Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY USA
关键词
automated analyzers; cerebrospinal fluid; lumbar puncture; manual microscopy; pleocytosis; BODY-FLUID MODE; FLOW-CYTOMETRIC ANALYSIS; CEREBROSPINAL-FLUID; HEMATOLOGY ANALYZER; BLOOD-CELLS; PERFORMANCE EVALUATION; SYSMEX XE-5000; MODULE; WHITE; XN-1000;
D O I
10.1111/ijlh.14236
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This systematic review evaluates the evidence for accuracy of automated analyzers that estimate cerebrospinal fluid (CSF) white blood cell counts (WBC) compared to manual microscopy. Inclusion criteria of original research articles included human subjects, English language, and manual microscopy comparator. PUBMED, EMBASE and Cochrane Review databases were searched through 2019 and QUADAS-2 Tool was used for assessment of bias. Data were pooled and analyzed by comparison method, using random effects estimation. Among 652 titles, 554 abstracts screened, 104 full-text review, 111 comparisons from 41 studies were included. Pooled estimates of sensitivity and specificity (n = 7) were 95% (95%-CI 93%-97%) and 84% (95%-CI: 64%-96%), respectively. Pooled R-2 estimates (n = 29) were 0.95 (95%-CI: 0.95-0.96); Pooled spearman rho correlation (n = 27) estimates were 0.95 (95% CI 0.95-0.96). Among those comparisons using Bland-Altman analysis (n = 11) pooled mean difference was estimated at 0.98 (95% CI-0.54-2.5). Among comparisons using Passing-Bablok regressions (n = 14) the pooled slope was estimated to be 1.05 (95% CI 1.03-1.07). Q tests of homogeneity were all significant with the exception of the Bland-Altman comparisons (I-2 10%, p value 0.35). There is good overall accuracy for CSF WBC by automated hematologic analyzers. These findings are limited by the small sample sizes and inconsistent validation methodology in the reviewed studies.
引用
收藏
页码:234 / 242
页数:9
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