Whole-exome sequencing explored mechanism of selpercatinib resistance in RET-rearranged lung adenocarcinoma transformation into small-cell lung cancer: a case report

被引：5

作者：

Yan, Peng ^{[1
]}

Zhu, Zheng ^{[2
]}

Zewen, Wang ^{[1
]}

Liu, Yanan ^{[1
]}

Zhang, Mingyan ^{[3
]}

Sun, Meili ^{[1
]}

机构：

[1] Shandong First Med Univ, Cent Hosp Affiliated, Oncol Dept, Jinan, Peoples R China

[2] PLA Rocket Force Characterist Med Ctr, Res Dept, Beijing, Peoples R China

[3] Shandong Univ, Sch Med, Jinan, Peoples R China

来源：

BMC PULMONARY MEDICINE | 2023年 / 23卷 / 01期

关键词：

NSCLC; RET-rearranged; Whole-exome sequencing; Small cell transformation; MUTATIONAL PROCESSES; CARCINOMAS;

D O I：

10.1186/s12890-023-02799-5

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Small cell transformation was one mechanism by which EGFR-mutation NSCLC acquired resistance after tyrosine kinase inhibitors (TKIs) treatment. A few reports of small cell transformation occurred in other oncogene-driven lung cancers. We found the first case of transformation of a RET-rearranged lung adenocarcinoma to SCLC after selpercatinib, a novel highly selective RET TKIs. Whole-exome sequencing (WES) was used to explore alteration in gene expression in tumor tissue at initial diagnosis and after transformation into small cell carcinoma. We found that transformed into SCLC tumor tissue had inactivation of RB1 and TP53, with RET fusion was still present. In addition, the APOBEC family of cytidine deaminases appeared amplification. Although RET rearrangement still existed, using another RET TKIs was ineffective, and etoposide plus platinum might be an effective rescue treatment.

引用

页数：9

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