Two-step synthesis of indeno[1,2-b]furazanopyrazines through combination of the SNH and Heck reactions

被引：1

作者：

Kvashnin, Yuriy A. ^{[1
,2
]}

Belyaev, Danila V. ^{[1
,3
]}

Kodess, Mikhail I. ^{[1
]}

Ezhikova, Marina A. ^{[1
]}

Rusinov, Gennady L. ^{[1
,2
]}

Verbitskiy, Egor V. ^{[1
,2
]}

Charushin, Valery N. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Ural Branch, IYa Postovsky Inst Organ Synth, Ekaterinburg 620137, Russia

[2] Ural Fed Univ, Inst Chem Engn, Ekaterinburg 620002, Russia

[3] Natl Med Res Ctr Phthisiopulmonol & Infect Dis, Ural Res Inst Phthisiopulmonol, Ekaterinburg 620039, Russia

来源：

MENDELEEV COMMUNICATIONS | 2023年 / 33卷 / 06期

关键词：

furazanopyrazines; 1; 2; 5]oxadiazolo[3; 4-b]pyrazines; intramolecular Heck reaction; C-H functionalization; SNH reactions; antimycobacterials; indeno[1; 2-b][1; 4-e]pyrazines; DERIVATIVES; SYSTEMS;

D O I：

10.1016/j.mencom.2023.10.004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enamines generated in situ from aliphatic amines and acetone react with 5-(2-bromophenyl)furazano[3,4-b]pyrazines via the nucleophilic substitution of hydrogen atom of the pyrazine ring. A representative of 9H-indeno[1,2-b]furazanopyrazin-9-ylidene ring system has been accessed by exploiting the intramolecular Heck cyclization of the obtained SNH-product. Several compounds derived from furazano[3,4-b]pyrazin-5-yl]prop-1-en-2-amines, proved to exhibit a bacteriostatic activity in vitro against Mycobacterium tuberculosis H37Rv.

引用

页码：753 / 755

页数：3

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