Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human Body

被引:0
作者
Choi, Sun-Haeng [1 ,2 ]
Ochirpurev, Bolormaa [3 ]
Toriba, Akira [4 ]
Won, Jong-Uk [2 ]
Kim, Heon [1 ,3 ]
机构
[1] Chungbuk Natl Univ Hosp, Dept Occupat & Environm Med, Cheongju 28644, South Korea
[2] Yonsei Univ, Grad Sch, Dept Publ Hlth, Seoul 03722, South Korea
[3] Chungbuk Natl Univ, Coll Med, Dept Prevent Med, Cheongju 28644, South Korea
[4] Nagasaki Univ, Grad Sch Biomed Sci, Dept Hyg Chem, Nagasaki 8528521, Japan
关键词
polycyclic aromatic hydrocarbons; benzo[a]pyrene; 1-nitropyrene; oxidative stress; thiobarbituric acid-reactive substances; 8-hydroxydeoxyguanosine; POLYCYCLIC AROMATIC-HYDROCARBONS; PERFORMANCE LIQUID-CHROMATOGRAPHY; DIESEL EXHAUST; DNA-DAMAGE; MUTAGENICITY; METABOLITES; MINERS; URINE; AIR;
D O I
10.3390/toxics11090797
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Polycyclic aromatic hydrocarbons (PAHs) have been reported to cause oxidative stress in metabolic processes. This study aimed to evaluate the relationship between exposure to PAHs, including benzo[a]pyrene (BaP) and 1-nitropyrene (1-NP), in the atmosphere and oxidative stress levels in the human body. This study included 44 Korean adults who lived in Cheongju, Republic of Korea. Atmospheric BaP and 1-NP concentrations and urinary 6-hydroxy-1-nitropyrene (6-OHNP), N-acetyl-1-aminopyrene (1-NAAP), and 1-hydroxypyrene (1-OHP) concentrations were measured. The oxidative stress level was assessed by measuring urinary thiobarbituric acid-reactive substances (TBARS) and 8-hydroxydeoxyguanosine (8-OHdG) concentrations. Urinary TBARS and 6-OHNP concentrations significantly differed between winter and summer. BaP exposure was significantly associated with urinary 8-OHdG concentrations in summer. However, atmospheric 1-NP did not show a significant correlation with oxidative stress marker concentrations. Urinary 1-NAAP concentration was a significant determinant for urinary 8-OHdG concentration in summer. Oxidative stress in the body increases in proportion to inhalation exposure to BaP, and more 8-OHdG is produced in the body as the amount of 1-NP, which is metabolized to 1-AP or 1-NAAP, increases.
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页数:11
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