Brown adipose tissue-derived metabolites and their role in regulating metabolism

被引：12

作者：

Ziqubu, Khanyisani ^{[1
]}

Dludla, Phiwayinkosi, V ^{[2
,3
]}

Mabhida, Sihle E. ^{[4
]}

Jack, Babalwa U. ^{[5
]}

Keipert, Susanne ^{[6
]}

Jastroch, Martin ^{[6
]}

Mazibuko-Mbeje, Sithandiwe E. ^{[1
,7
]}

机构：

[1] North West Univ, Dept Biochem, ZA-2745 Mafikeng, South Africa

[2] South African Med Res Council, Cochrane South Africa, ZA-7505 Tygerberg, South Africa

[3] Univ Zululand, Fac Sci & Agr, Dept Biochem & Microbiol, ZA-3886 Kwa Dlangezwa, South Africa

[4] South African Med Res Council, Noncommunicable Dis Res Unit, ZA-7505 Tygerberg, South Africa

[5] South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa

[6] Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden

[7] North West Univ, Dept Biochem, Fac Nat & Agr Sci, Mafikeng Campus,Private Bag X 2046, ZA-2735 Mmabatho, South Africa

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2024年 / 150卷

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

Brown adipose tissue; Batokines; Metabolites; Secretome; Metabolism; Obesity; Metabolic diseases; BETA-ADRENERGIC STIMULATION; PROTEIN-COUPLED RECEPTORS; PROSTAGLANDIN D SYNTHASE; NERVE GROWTH-FACTOR; GENE-EXPRESSION; NITRIC-OXIDE; ADIPOCYTE DIFFERENTIATION; ENERGY-EXPENDITURE; L-CARNITINE; FAT-CELLS;

D O I：

10.1016/j.metabol.2023.155709

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult humans have offered a new approach to treat obesity and metabolic diseases. Beyond its accomplished role in adaptive thermogenesis, BAT secretes signaling molecules known as "batokines", which are instrumental in regulating whole-body metabolism via autocrine, paracrine, and endocrine action. In addition to the intrinsic BAT metaboliteoxidizing activity, the endocrine functions of these molecules may help to explain the association between BAT activity and a healthy systemic metabolic profile. Herein, we review the evidence that underscores the significance of BAT-derived metabolites, especially highlighting their role in controlling physiological and metabolic processes involving thermogenesis, substrate metabolism, and other essential biological processes. The conversation extends to their capacity to enhance energy expenditure and mitigate features of obesity and its related metabolic complications. Thus, metabolites derived from BAT may provide new avenues for the discovery of metabolic health-promoting drugs with far-reaching impacts. This review aims to dissect the complexities of the secretory role of BAT in modulating local and systemic metabolism in metabolic health and disease.

引用

页数：20

共 284 条

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