Role of aldosterone and mineralocorticoid receptor (MR) in addiction: A scoping review

被引：4
作者：
Pince, Claire L. [1 ,2 ,3 ,4 ]
Whiting, Kimberly E. [1 ,2 ,3 ]
Wang, Tammy [1 ,2 ]
Leko, Andras H. [1 ,2 ,5 ]
Farinelli, Lisa A. [1 ,2 ]
Cooper, Diane [6 ]
Farokhnia, Mehdi [1 ,2 ]
Vendruscolo, Leandro F. [2 ,4 ]
Leggio, Lorenzo [1 ,2 ]
机构：
[1] NIDA, Clin Psychoneuroendocrinol & Neuropsychopharmacol, Translat Addict Med Branch, Intramural Res Program, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA
[2] NIAAA, Div Intramural Clin & Biol Res, NIH, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA
[3] NIDA, Neurobiol Addict Sect, Integrat Neurosci Res Branch, Intramural Res Program,NIH, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA
[4] NIDA, Stress & Addict Neurosci Unit, Integrat Neurosci Res Branch, Intramural Res Program, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA
[5] NIH, Ctr Compuls Behav, Intramural Res Program, Bethesda, MD 20892 USA
[6] NIH, Off Res Serv, Div Lib Serv, Bldg 10, Bethesda, MD 20892 USA
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2023年 / 154卷
基金：
美国国家卫生研究院;
关键词：
Alcohol; Aldosterone; Mineralocorticoid Receptor; Opioid; Spironolactone; Stimulants; PITUITARY-ADRENAL AXIS; RENIN-ANGIOTENSIN SYSTEM; NICOTINE WITHDRAWAL SYMPTOMS; CONVERTING-ENZYME-INHIBITOR; VOLUNTARY ALCOHOL INTAKE; GLUCOCORTICOID-RECEPTOR; PLASMA-CORTICOSTERONE; ANXIETY SENSITIVITY; NUCLEUS-ACCUMBENS; SODIUM DEPLETION;
D O I：
10.1016/j.neubiorev.2023.105427
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Preclinical and human studies suggest a role of aldosterone and mineralocorticoid receptor (MR) in addiction. This scoping review aimed to summarize (1) the relationship between alcohol and other substance use disorders (ASUDs) and dysfunctions of the aldosterone and MR, and (2) how pharmacological manipulations of MR may affect ASUD-related outcomes. Our search in four databases (MEDLINE, Embase, Web of Science, and Cochrane Library) indicated that most studies focused on the relationship between aldosterone, MR, and alcohol (n = 30), with the rest focused on opioids (n = 5), nicotine (n = 9), and other addictive substances (n = 9). Despite some inconsistencies, the overall results suggest peripheral and central dysregulations of aldosterone and MR in several species and that these dysregulations depended on the pattern of drug exposure and genetic factors. We conclude that MR antagonism may be a promising target in ASUD, yet future studies are warranted.
引用
收藏
页数：24
相关论文
共 166 条
[51]  
GRUPP LA, 1992, ALCOHOL ALCOHOLISM, V27, P267
[52]   EFFECTS OF ANGIOTENSIN-II AND AN ANGIOTENSIN CONVERTING-ENZYME-INHIBITOR ON ALCOHOL INTAKE IN P AND NP RATS [J].
GRUPP, LA .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1992, 41 (01) :105-108
[53]   REGULATION OF ALCOHOL-CONSUMPTION BY THE RENIN-ANGIOTENSIN SYSTEM - A REVIEW OF RECENT FINDINGS AND A POSSIBLE MECHANISM OF ACTION [J].
GRUPP, LA ;
PERLANSKI, E ;
STEWART, RB .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1991, 15 (02) :265-275
[54]   Neurotensin attenuates the reduction in alcohol drinking produced by angiotensin II [J].
Grupp, LA ;
Harding, S .
PSYCHOPHARMACOLOGY, 1996, 125 (01) :57-64
[55]   ANGIOTENSIN-II REDUCES VOLUNTARY ALCOHOL INTAKE IN THE RAT [J].
GRUPP, LA ;
KILLIAN, M ;
PERLANSKI, E ;
STEWART, RB .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 29 (03) :479-482
[56]  
GRUPP LA, 1991, ALCOHOL ALCOHOLISM, P421
[57]   Mifepristone as a pharmacological intervention for stress-induced alcohol craving: A human laboratory study [J].
Haass-Koffler, Carolina L. ;
Magill, Molly ;
Cannella, Nazzareno ;
Brown, Joshua C. ;
Aoun, Elie G. ;
Cioe, Patricia A. ;
Sinha, Rajita ;
Swift, Robert M. ;
Ciccocioppo, Roberto ;
Leggio, Lorenzo .
ADDICTION BIOLOGY, 2023, 28 (07)
[58]   Intravenous administration of ghrelin increases serum cortisol and aldosterone concentrations in heavy-drinking alcohol-dependent individuals: Results from a double-blind, placebo-controlled human laboratory study [J].
Haass-Koffler, Carolina L. ;
Long, Victoria M. ;
Farokhnia, Mehdi ;
Magill, Molly ;
Kenna, George A. ;
Swift, Robert M. ;
Leggio, Lorenzo .
NEUROPHARMACOLOGY, 2019, 158
[59]   Contrasting renal effects of nicotine in smokers and non-smokers [J].
Halimi, JM ;
Philippon, C ;
Mimran, A .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 1998, 13 (04) :940-944
[60]   Vasopressin and alcohol: a multifaceted relationship [J].
Harper, Kathryn M. ;
Knapp, Darin J. ;
Criswell, Hugh E. ;
Breese, George R. .
PSYCHOPHARMACOLOGY, 2018, 235 (12) :3363-3379
12345678910