Role of aldosterone and mineralocorticoid receptor (MR) in addiction: A scoping review

被引：4

作者：

Pince, Claire L. ^{[1
,2
,3
,4
]}

Whiting, Kimberly E. ^{[1
,2
,3
]}

Wang, Tammy ^{[1
,2
]}

Leko, Andras H. ^{[1
,2
,5
]}

Farinelli, Lisa A. ^{[1
,2
]}

Cooper, Diane ^{[6
]}

Farokhnia, Mehdi ^{[1
,2
]}

Vendruscolo, Leandro F. ^{[2
,4
]}

Leggio, Lorenzo ^{[1
,2
]}

机构：

[1] NIDA, Clin Psychoneuroendocrinol & Neuropsychopharmacol, Translat Addict Med Branch, Intramural Res Program, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA

[2] NIAAA, Div Intramural Clin & Biol Res, NIH, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA

[3] NIDA, Neurobiol Addict Sect, Integrat Neurosci Res Branch, Intramural Res Program,NIH, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA

[4] NIDA, Stress & Addict Neurosci Unit, Integrat Neurosci Res Branch, Intramural Res Program, 251 Bayview Blvd,Suite 200, Baltimore, MD 21224 USA

[5] NIH, Ctr Compuls Behav, Intramural Res Program, Bethesda, MD 20892 USA

[6] NIH, Off Res Serv, Div Lib Serv, Bldg 10, Bethesda, MD 20892 USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2023年 / 154卷

基金：

美国国家卫生研究院;

关键词：

Alcohol; Aldosterone; Mineralocorticoid Receptor; Opioid; Spironolactone; Stimulants; PITUITARY-ADRENAL AXIS; RENIN-ANGIOTENSIN SYSTEM; NICOTINE WITHDRAWAL SYMPTOMS; CONVERTING-ENZYME-INHIBITOR; VOLUNTARY ALCOHOL INTAKE; GLUCOCORTICOID-RECEPTOR; PLASMA-CORTICOSTERONE; ANXIETY SENSITIVITY; NUCLEUS-ACCUMBENS; SODIUM DEPLETION;

D O I：

10.1016/j.neubiorev.2023.105427

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Preclinical and human studies suggest a role of aldosterone and mineralocorticoid receptor (MR) in addiction. This scoping review aimed to summarize (1) the relationship between alcohol and other substance use disorders (ASUDs) and dysfunctions of the aldosterone and MR, and (2) how pharmacological manipulations of MR may affect ASUD-related outcomes. Our search in four databases (MEDLINE, Embase, Web of Science, and Cochrane Library) indicated that most studies focused on the relationship between aldosterone, MR, and alcohol (n = 30), with the rest focused on opioids (n = 5), nicotine (n = 9), and other addictive substances (n = 9). Despite some inconsistencies, the overall results suggest peripheral and central dysregulations of aldosterone and MR in several species and that these dysregulations depended on the pattern of drug exposure and genetic factors. We conclude that MR antagonism may be a promising target in ASUD, yet future studies are warranted.

引用

页数：24

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