Photoredox-Catalyzed Trifunctionalization of 5-Heteroaryl-Substituted 1-Hexenes or 5-hexenenitriles via Remote Heteroaryl or Cyano Group Migration

被引：6

作者：

Guo, Kang ^{[1
]}

机构：

[1] Hebei Normal Univ Nationalities, Chengde 067000, Hebei, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 21期

关键词：

trifunctionalization; heteroaryl migration; cyano migration; photoredox catalysis; TRANSFER RADICAL-ADDITION; UNACTIVATED ALKENES; DIFUNCTIONALIZATION; OXIDATION; ARYL; TRIFLUOROMETHYLATION; FLUORINE; STRATEGY;

D O I：

10.1002/adsc.202300805

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A photoredox-catalyzed trifunctionalization of 5-heteroaryl-substituted 1-hexenes via remote heteroaryl migration and a photoredox-catalyzed trifunctionalization of 5-hexenenitriles via cyano migration are reported. This protocol provides access to a broad scope of CFnR-containing ketones with high molecular complexity and functional group diversity. The reaction features mild conditions and high chemo- and regioselectivities. The success of gram-scale reactions and the versatility of products in derivative synthesis illustrated the potential value of this transformation in synthetic chemistry.

引用

页码：3616 / 3621

页数：6

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