Photoredox-Catalyzed Trifunctionalization of 5-Heteroaryl-Substituted 1-Hexenes or 5-hexenenitriles via Remote Heteroaryl or Cyano Group Migration

A photoredox-catalyzed trifunctionalization of 5-heteroaryl-substituted 1-hexenes via remote heteroaryl migration and a photoredox-catalyzed trifunctionalization of 5-hexenenitriles via cyano migration are reported. This protocol provides access to a broad scope of CFnR-containing ketones with high molecular complexity and functional group diversity. The reaction features mild conditions and high chemo- and regioselectivities. The success of gram-scale reactions and the versatility of products in derivative synthesis illustrated the potential value of this transformation in synthetic chemistry.