Application of Quinoline Ring in Structural Modification of Natural Products

被引：22

作者：

Zhao, Yu-Qing ^{[1
]}

Li, Xiaoting ^{[1
]}

Guo, Hong-Yan ^{[1
]}

Shen, Qing-Kun ^{[1
]}

Quan, Zhe-Shan ^{[1
]}

Luan, Tian ^{[2
]}

机构：

[1] Yanbian Univ, Coll Pharm, Key Lab Nat Med Changbai Mt, Minist Educ, Yanji 133002, Peoples R China

[2] Shenyang Med Coll, Dept Pharm, Shenyang 110034, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 18期

基金：

中国国家自然科学基金;

关键词：

natural products; quinoline; pharmacological activities; BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; ANTIBACTERIAL ACTIVITY; STEROIDAL DERIVATIVES; ANTITUMOR ACTIVITIES; CINCHONA ALKALOIDS; POTENT INHIBITORS; SIDE-CHAIN; DESIGN; ANALOGS;

D O I：

10.3390/molecules28186478

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural compounds are rich in pharmacological properties that are a hot topic in pharmaceutical research. The quinoline ring plays important roles in many biological processes in heterocycles. Many pharmacological compounds, including saquinavir and chloroquine, have been marketed as quinoline molecules with good anti-viral and anti-parasitic properties. Therefore, in this review, we summarize the medicinal chemistry of quinoline-modified natural product quinoline derivatives that were developed by several research teams in the past 10 years and find that these compounds have inhibitory effects on bacteria, viruses, parasites, inflammation, cancer, Alzheimer's disease, and others.

引用

页数：69

共 107 条

[51] Maddela Srinubabu, 2016, Anti-Infective Agents, V14, P53, DOI 10.2174/221135251401160302151229
[52] X-ray and molecular modelling in fragment-based design of three small quinoline scaffolds for HIV integrase inhibitors
Majerz-Maniecka, Katarzyna
Musiol, Robert
Skorska-Stania, Agnieszka
Tabak, Dominik
Mazur, Pawel
Oleksyn, Barbara J.
Polanski, Jaroslaw
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (05) : 1606 - 1612
[53] Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors
Mantoani, Susimaire P.
Chierrito, Talita P. C.
Vilela, Adriana F. L.
Cardoso, Carmen L.
Martinez, Ana
Carvalho, Ivone
[J]. MOLECULES, 2016, 21 (02)
[54] Synthesis and biological evaluation of heterocyclic analogues of pregnenolone as novel anti-osteoporotic agents
Maurya, Saransh Wales
Dev, Kapil
Singh, Krishna Bhan
Rai, Reena
Siddiqui, Ibadur Rahman
Singh, Divya
Maurya, Rakesh
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (06) : 1390 - 1396
[55] Design and synthesis of novel quinoline-aminopiperidine hybrid analogues as Mycobacterium tuberculosis DNA gyraseB inhibitors
Medapi, Brahmam
Renuka, Janupally
Saxena, Shalini
Sridevi, Jonnalagadda Padma
Medishetti, Raghavender
Kulkarni, Pushkar
Yogeeswari, Perumal
Sriram, Dharmarajan
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (09) : 2062 - 2078
[56] Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases
Mohassab, Aliaa M.
Hassan, Heba A.
Abdelhamid, Dalia
Gouda, Ahmed M.
Youssif, Bahaa G. M.
Tateishi, Hiroshi
Fujita, Mikako
Otsuka, Masami
Abdel-Aziz, Mohamed
[J]. BIOORGANIC CHEMISTRY, 2021, 106
[57] Quinoline-Based Antifungals
Musiol, R.
Serda, M.
Hensel-Bielowka, S.
Polanski, J.
[J]. CURRENT MEDICINAL CHEMISTRY, 2010, 17 (18) : 1960 - 1973
[58] Design and Synthesis of π-Extended Resveratrol Analogues and In Vitro Antioxidant and Anti-Inflammatory Activity Evaluation
Nam, Ki Yoon
Damodar, Kongara
Lee, Yeontaek
Park, Lee Seul
Gim, Ji Geun
Park, Jae Phil
Jeon, Seong Ho
Lee, Jeong Tae
[J]. MOLECULES, 2021, 26 (03):
[59] Synthesis and therapeutic potential of quinoline derivatives
Narwal, Sangeeta
Kumar, Sanjiv
Verma, Prabhakar Kumar
[J]. RESEARCH ON CHEMICAL INTERMEDIATES, 2017, 43 (05) : 2765 - 2798
[60] Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
Newman, David J.
Cragg, Gordon M.
[J]. JOURNAL OF NATURAL PRODUCTS, 2020, 83 (03): : 770 - 803

← 1 2 3 4 5 6 7 8 9 10 →