Application of Quinoline Ring in Structural Modification of Natural Products

被引：22
作者：
Zhao, Yu-Qing [1 ]
Li, Xiaoting [1 ]
Guo, Hong-Yan [1 ]
Shen, Qing-Kun [1 ]
Quan, Zhe-Shan [1 ]
Luan, Tian [2 ]
机构：
[1] Yanbian Univ, Coll Pharm, Key Lab Nat Med Changbai Mt, Minist Educ, Yanji 133002, Peoples R China
[2] Shenyang Med Coll, Dept Pharm, Shenyang 110034, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 18期
基金：
中国国家自然科学基金;
关键词：
natural products; quinoline; pharmacological activities; BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; ANTIBACTERIAL ACTIVITY; STEROIDAL DERIVATIVES; ANTITUMOR ACTIVITIES; CINCHONA ALKALOIDS; POTENT INHIBITORS; SIDE-CHAIN; DESIGN; ANALOGS;
D O I：
10.3390/molecules28186478
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Natural compounds are rich in pharmacological properties that are a hot topic in pharmaceutical research. The quinoline ring plays important roles in many biological processes in heterocycles. Many pharmacological compounds, including saquinavir and chloroquine, have been marketed as quinoline molecules with good anti-viral and anti-parasitic properties. Therefore, in this review, we summarize the medicinal chemistry of quinoline-modified natural product quinoline derivatives that were developed by several research teams in the past 10 years and find that these compounds have inhibitory effects on bacteria, viruses, parasites, inflammation, cancer, Alzheimer's disease, and others.
引用
收藏
页数：69
相关论文
共 107 条
  • [1] Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity
    Abonia, Rodrigo
    Insuasty, Daniel
    Castillo, Juan
    Insuasty, Braulio
    Quiroga, Jairo
    Nogueras, Manuel
    Cobo, Justo
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 57 : 29 - 40
  • [2] Design, synthesis and biological evaluation of fused naphthofuro[3,2-c]quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma
    Aly, Ashraf A.
    El-Sheref, Essmat M.
    Bakheet, Momtaz E. M.
    Mourad, Mai A. E.
    Brase, Stefan
    Ibrahim, Mahmoud A. A.
    Nieger, Martin
    Garvalov, Boyan K.
    Dalby, Kevin N.
    Kaoud, Tamer S.
    [J]. BIOORGANIC CHEMISTRY, 2019, 82 : 290 - 305
  • [3] Chemical synthesis, cytotoxicity, selectivity and bioavailability of 5α-androstane-3α, 17β-diol derivatives
    Ayan, Diana
    Maltais, Rene
    Hospital, Audrey
    Poirier, Donald
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (21) : 5847 - 5859
  • [4] Microwave-assisted one-pot synthesis of steroid-quinoline hybrids and an evaluation of their antiproliferative activities on gynecological cancer cell lines
    Baji, Adam
    Gyovai, Andras
    Woelfling, Janos
    Minorics, Renata
    Ocsovszki, Imre
    Zupko, Istvan
    Frank, Eva
    [J]. RSC ADVANCES, 2016, 6 (33) : 27501 - 27516
  • [5] Ultrasound-promoted synthesis, biological evaluation and molecular docking of novel 7-(2-chloroquinolin-4-yloxy)-4-methyl-2H-chromen-2-one derivatives
    Balaji, G. L.
    Rajesh, K.
    Priya, R.
    Iniyavan, P.
    Siva, R.
    Vijayakumar, V.
    [J]. MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (07) : 3185 - 3192
  • [6] Glycyrrhetinic acid derivatives as Zika virus inhibitors: Synthesis and antiviral activity in vitro
    Baltina, Lidia A.
    Lai, Hsueh-Chou
    Liu, Ya-Chi
    Huang, Su-Hua
    Hour, Mann-Jen
    Baltina, Lia A.
    Nugumanov, Tagir R.
    Borisevich, Sophia S.
    Khalilov, Leonard M.
    Petrova, Svetlana F.
    Khursan, Sergey L.
    Lin, Cheng-Wen
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 41
  • [7] Synthesis, antioxidant and Aβ anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction
    Benchekroun, Mohamed
    Pachon-Angona, Irene
    Luzet, Vincent
    Martin, Helene
    Oset-Gasque, Maria-Jesus
    Marco-Contelles, Jose
    Ismaili, Lhassane
    [J]. BIOORGANIC CHEMISTRY, 2019, 85 : 221 - 228
  • [8] Structurally modified glycyrrhetinic acid derivatives as anti-inflammatory agents
    Bian, Ming
    Zhen, Dong
    Shen, Qing-Kun
    Du, Huan-Huan
    Ma, Qian-Qian
    Quan, Zhe-Shan
    [J]. BIOORGANIC CHEMISTRY, 2021, 107
  • [9] Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB
    Campanico, Andre
    Carrasco, Marta P.
    Njoroge, Mathew
    Seldon, Ronnett
    Chibale, Kelly
    Perdigao, Joao
    Portugal, Isabel
    Warner, Digby F.
    Moreira, Rui
    Lopes, Francisca
    [J]. CHEMMEDCHEM, 2019, 14 (16) : 1537 - 1546
  • [10] Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety
    Chaudhary, Vikas
    Venghateri, Jubina B.
    Dhaked, Hemendra P. S.
    Bhoyar, Anil S.
    Guchhait, Sankar K.
    Panda, Dulal
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (07) : 3439 - 3451
12345678910