Array of Nanopore Sensors Detect Nanoscale Biomolecules by Nucleic Acid Analysis

As a powerful technology, Array nanomaterials technology is widely used in the detection of biomolecules because the analytes of interest are detected and analyzed within a nanovolume. The solid-state nanopore array has a vast diversity of platforms and applications, such as improving the detection sensitivity of single molecules, achieving the goals of target detection, elevating the performance of anti-interference and realizing high-throughput and real-time measurement. It has made breakthrough progress in the qualitative and quantitative detection of various targets. However, no single review can cover the entire landscape of published work in the field. This article does not aim to cite all articles relating to solid-state nanopore arrays, but rather aims to highlight recent, select developments that will hopefully benefit new and seasoned scientists alike. Initially, the structure fabrication methods used in solid-state nanopore detection that apply transmission electron microscopes (TEMs), chemical etching, focused ion/electron beams (FIB/FEB), will be introduced. Then, the next section is devoted to highlighting various surface functionalization methods. Finally, this review focuses on arrayed nanopores, as nucleic acid sensing technologies have great potential applications in the detection and measurement of DNA, RNA, protein and other analytes (such as new agents, bacteria, viruses, nanoparticles and polysaccharides).