Resolution of persistent SARS-CoV-2 infection with prolonged intravenous remdesivir and vaccination in a patient post CAR-T

被引：7

作者：

Ambati, Sai ^{[1
]}

Ali, Bazga ^{[2
]}

Seddon, Owen ^{[2
]}

Godkin, Andrew ^{[3
]}

Scurr, Martin ^{[4
]}

Moore, Catherine ^{[5
]}

Rowntree, Clare ^{[6
]}

Underwood, Jonathan ^{[7
]}

机构：

[1] Univ Hosp Wales, Cardiff & Vale Univ Hlth Board, Dept Internal Med, Cardiff, Wales

[2] Cardiff & Vale Univ Hlth Board, Dept Infect Dis, Cardiff, Wales

[3] Cardiff Univ, Cardiff & Vale Univ Hlth Board, Sch Med, Dept Gastroenterol & Hepatol,Div Infect & Immun, Cardiff, Wales

[4] Cardiff Univ, Sch Med, Div Infect & Immun, ImmunoServ Ltd, Cardiff, Wales

[5] Cardiff & Vale Univ, Dept Virol, Cardiff, Wales

[6] Cardiff & Vale Univ Hlth Board, Dept Haematol, Cardiff, Wales

[7] Cardiff Univ, Cardiff & Vale Univ Hlth Board, Sch Med, Dept Infect Dis,Div Infect & Immun, Cardiff, Wales

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2023年 / 117卷 / 05期

关键词：

SARS-CoV-2; Remdesivir; B cell ALL; Post BMT; CAR-T therapy; COVID-19; CELL;

D O I：

10.1007/s12185-022-03518-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SARS-CoV-2 virus is a single-stranded enveloped RNA virus, which causes coronavirus disease. Most of the immunocompetent patients with SARS-CoV-2 infection do have mild to moderate respiratory illness; however, in immunocompromised patients, the course of infection is unpredictable with high rates of infectivity and mortality. So, it is important to identify the immunocompromised patients early and establish the course of treatment accordingly. Here, we describe a 25-year-old male with background of B cell ALL, post-BMT and CAR-T therapy who received treatment with remdesivir and vaccination and was followed up for six months from the onset of symptoms to post vaccination, which showed resolution of symptoms and improvement of immunological markers. Here, we review the literature concerning the course and treatment of SARS-CoV-2 infection aimed at achieving cure in this patient.

引用

页码：765 / 768

页数：4

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