Mucosal and hormonal adaptations after Roux-en-Y gastric bypass

被引：8
作者：
Feris, Fauzi [1 ]
McRae, Alison [1 ]
Kellogg, Todd A. [2 ]
McKenzie, Travis [2 ]
Ghanem, Omar [2 ]
Acosta, Andres [1 ,3 ]
机构：
[1] Mayo Clin, Dept Med, Precis Med Obes Program, Div Gastroenterol & Hepatol, Rochester, MN 55902 USA
[2] Mayo Clin, Dept Surg, Div Endocrine & Metab Surg, Rochester, MN 55902 USA
[3] Mayo Clin, Charlton 8-142,200 First St SW, Rochester, MN 55902 USA
来源：
SURGERY FOR OBESITY AND RELATED DISEASES | 2023年 / 19卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Metabolic adaptations; Roux-en-Y gastric bypass; Gastric bypass; Bariatric surgery; Obesity; Gut hormones; Satiety hormones; Mucosal adaptations; GLUCAGON-LIKE PEPTIDE-1; DEPENDENT INSULINOTROPIC POLYPEPTIDE; ISLET AMYLOID POLYPEPTIDE; BETA-CELL FUNCTION; RECEPTOR AGONIST TIRZEPATIDE; WEIGHT-LOSS; INHIBITORY POLYPEPTIDE; GUT HORMONE; FOOD-INTAKE; BILE-ACIDS;
D O I：
10.1016/j.soard.2022.08.020
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The aim of this study was to perform a comprehensive literature review regarding the relevant hor-monal and histologic changes observed after Roux-en-Y gastric bypass (RYGB). We aimed to describe the relevant hormonal (glucagon-like peptides 1 and 2 [GLP-1 and GLP-2], peptide YY [PYY], oxyntomodulin [OXM], bile acids [BA], cholecystokinin [CCK], ghrelin, glucagon, gastric inhibitory polypeptide [GIP], and amylin) profiles, as well as the histologic (mucosal cellular) adap-tations happening after patients undergo RYGB. Our review compiles the current evidence and fur-thers the understanding of the rationale behind the food intake regulatory adaptations occurring after RYGB surgery. We identify gaps in the literature where the potential for future investigations and therapeutics may lie. We performed a comprehensive database search without language restrictions looking for RYGB bariatric surgery outcomes in patients with pre-and postoperative blood work hor-monal profiling and/or gut mucosal biopsies. We gathered the relevant study results and describe them in this review. Where human findings were lacking, we included animal model studies. The amalgam-ation of physiologic, metabolic, and cellular adaptations following RYGB is yet to be fully charac-terized. This constitutes a fundamental aspiration for enhancing and individualizing obesity therapy. (Surg Obes Relat Dis 2023;19:37-49.) (c) 2023 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：37 / 49
页数：13
相关论文
共 170 条
[1]   Blockade of the neuropeptide YY2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake [J].
Abbott, CR ;
Small, CJ ;
Kennedy, AR ;
Neary, NM ;
Sajedi, A ;
Ghatei, MA ;
Bloom, SR .
BRAIN RESEARCH, 2005, 1043 (1-2) :139-144
[2]   The influence of the percentage of the common limb in weight loss and nutritional alterations after laparoscopic gastric bypass [J].
Abelian, Israel ;
Lujan, Juan ;
Frutos, Maria Dolores ;
Abrisqueta, Jesus ;
Hernandez, Quiteria ;
Lopez, Victor ;
Parrilla, Pascual .
SURGERY FOR OBESITY AND RELATED DISEASES, 2014, 10 (05) :829-833
[3]   Gastrojejunal Stoma Diameter Predicts Weight Regain After Roux-en-Y Gastric Bypass [J].
Abu Dayyeh, Barham K. ;
Lautz, David B. ;
Thompson, Christopher C. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2011, 9 (03) :228-233
[4]   Salivary PYY: A Putative Bypass to Satiety [J].
Acosta, Andres ;
Hurtado, Maria D. ;
Gorbatyuk, Oleg ;
La Sala, Michael ;
Duncan, David ;
Aslanidi, George ;
Campbell-Thompson, Martha ;
Zhang, Lei ;
Herzog, Herbert ;
Voutetakis, Antonis ;
Baum, Bruce J. ;
Zolotukhin, Sergei .
PLOS ONE, 2011, 6 (10)
[5]   Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake [J].
Adriaenssens, Alice E. ;
Biggs, Emma K. ;
Darwish, Tamana ;
Tadross, John ;
Sukthankar, Tanmay ;
Girish, Milind ;
Polex-Wolf, Joseph ;
Lam, Brain Y. ;
Zvetkova, Ilona ;
Pan, Warren ;
Chiarugi, Davide ;
Yeo, Giles S. H. ;
Blouet, Clemence ;
Gribble, Fiona M. ;
Reimann, Frank .
CELL METABOLISM, 2019, 30 (05) :987-+
[6]   Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity [J].
Ahmad, N. N. ;
Pfalzer, A. ;
Kaplan, L. M. .
INTERNATIONAL JOURNAL OF OBESITY, 2013, 37 (12) :1553-1559
[7]   Metabolic surgery and gut hormones - A review of bariatric entero-humoral modulation [J].
Ashrafian, Hutan ;
le Roux, Carel W. .
PHYSIOLOGY & BEHAVIOR, 2009, 97 (05) :620-631
[8]   Do the Actions of Glucagon-Like Peptide-1 on Gastric Emptying, Appetite, and Food Intake Involve Release of Amylin in Humans? [J].
Asmar, Meena ;
Bache, Michael ;
Knop, Filip K. ;
Madsbad, Sten ;
Holst, Jens J. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (05) :2367-2375
[9]   Factors associated with weight regain post-bariatric surgery: a systematic review [J].
Athanasiadis, Dimitrios I. ;
Martin, Anna ;
Kapsampelis, Panagiotis ;
Monfared, Sara ;
Stefanidis, Dimitrios .
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2021, 35 (08) :4069-4084
[10]   CHOLECYSTOKININ IS A SATIETY HORMONE IN HUMANS AT PHYSIOLOGICAL POSTPRANDIAL PLASMA-CONCENTRATIONS [J].
BALLINGER, A ;
MCLOUGHLIN, L ;
MEDBAK, S ;
CLARK, M .
CLINICAL SCIENCE, 1995, 89 (04) :375-381
12345678910