SLCO1B3 T334G polymorphisms and mycophenolate mofetil-related adverse reactions in kidney transplant recipients

被引：2
作者：
Zhong, Jianxun [1 ]
Yang, Kun [1 ]
Zhang, Mi [1 ]
Wu, Jianhua [1 ]
Liu, Liang [1 ]
机构：
[1] Wuhan Univ, Zhongnan Hosp, Dept Pharm, Wuhan 430070, Peoples R China
来源：
PHARMACOGENOMICS | 2023年 / 24卷 / 02期
基金：
中国国家自然科学基金;
关键词：
adverse effects; gene polymorphism; kidney transplantation; mycophenolate mofetil; PHENOLIC GLUCURONIDE METABOLITE; GENETIC POLYMORPHISMS; ACID; PHARMACOKINETICS; ASSOCIATION; MECHANISMS;
D O I：
10.2217/pgs-2022-0101
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: The correlation between SLCO1B3 T334G polymorphisms and mycophenolate mofetil (MMF) adverse reactions in kidney recipients is unknown. Methods: A single-center, retrospective study was performed in which 111 patients were divided into four groups according to the type of adverse effect experienced. The clinical data and concentrations of MMF at different months after transplantation were statistically analyzed. Results: The G allele in the gastrointestinal reaction group was significantly higher than that in the no adverse effects group (p < 0.05). Logistic regression model showed that the SLCO1B3 T334G genotype was an independent risk factor for gastrointestinal reactions caused by MMF. Conclusion: Patients with the SLCO1B3 T334G GG genotype were more likely to experience gastrointestinal reactions.
引用
收藏
页码：83 / 91
页数：9
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