Light-responsive biomaterials for ocular drug delivery

被引：20

作者：

Abdelmohsen, Hend A. M. ^{[1
,2
,3
]}

Copeland, Nikki A. ^{[2
,4
]}

Hardy, John G. ^{[1
,4
]}

机构：

[1] Univ Lancaster, Dept Chem, Lancaster LA1 4YB, Lancs, England

[2] Univ Lancaster, Div Biomed & Life Sci, Lancaster LA1 4YW, Lancs, England

[3] Ain Shams Univ, Fac Pharm, Dept Pharmaceut & Ind Pharm, African Union Org St, Cairo 11566, Egypt

[4] Univ Lancaster, Mat Sci Inst, Lancaster LA1 4YB, Lancs, England

来源：

DRUG DELIVERY AND TRANSLATIONAL RESEARCH | 2023年 / 13卷 / 08期

关键词：

Ocular drug delivery; Stimuli-responsive; Light-triggered; Light-responsive; Photochemistry; Photobiology; UP-CONVERSION NANOPARTICLES; CHEMO-PHOTOTHERMAL THERAPY; PHOTODYNAMIC THERAPY; PHOTOSENSITIZER DELIVERY; VISIBLE-LIGHT; PHOTOINITIATED DESTABILIZATION; UPCONVERTING NANOPARTICLES; ANTERIOR SEGMENT; AZOBENZENE; RELEASE;

D O I：

10.1007/s13346-022-01196-5

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Light-responsive biomaterials can be used for the delivery of therapeutic drugs and nucleic acids, where the tunable/precise delivery of payload highlights the potential of such biomaterials for treating a variety of conditions. The translucency of eyes and advances of laser technology in ophthalmology make light-responsive delivery of drugs feasible. Importantly, light can be applied in a non-invasive fashion; therefore, light-triggered drug delivery systems have great potential for clinical impact. This review will examine various types of light-responsive polymers and the chemistry that underpins their application as ophthalmic drug delivery systems.

引用

页码：2159 / 2182

页数：24

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