Light-responsive biomaterials for ocular drug delivery

被引：25
作者：
Abdelmohsen, Hend A. M. [1 ,2 ,3 ]
Copeland, Nikki A. [2 ,4 ]
Hardy, John G. [1 ,4 ]
机构：
[1] Univ Lancaster, Dept Chem, Lancaster LA1 4YB, Lancs, England
[2] Univ Lancaster, Div Biomed & Life Sci, Lancaster LA1 4YW, Lancs, England
[3] Ain Shams Univ, Fac Pharm, Dept Pharmaceut & Ind Pharm, African Union Org St, Cairo 11566, Egypt
[4] Univ Lancaster, Mat Sci Inst, Lancaster LA1 4YB, Lancs, England
来源：
DRUG DELIVERY AND TRANSLATIONAL RESEARCH | 2023年 / 13卷 / 08期
关键词：
Ocular drug delivery; Stimuli-responsive; Light-triggered; Light-responsive; Photochemistry; Photobiology; UP-CONVERSION NANOPARTICLES; CHEMO-PHOTOTHERMAL THERAPY; PHOTODYNAMIC THERAPY; PHOTOSENSITIZER DELIVERY; VISIBLE-LIGHT; PHOTOINITIATED DESTABILIZATION; UPCONVERTING NANOPARTICLES; ANTERIOR SEGMENT; AZOBENZENE; RELEASE;
D O I：
10.1007/s13346-022-01196-5
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Light-responsive biomaterials can be used for the delivery of therapeutic drugs and nucleic acids, where the tunable/precise delivery of payload highlights the potential of such biomaterials for treating a variety of conditions. The translucency of eyes and advances of laser technology in ophthalmology make light-responsive delivery of drugs feasible. Importantly, light can be applied in a non-invasive fashion; therefore, light-triggered drug delivery systems have great potential for clinical impact. This review will examine various types of light-responsive polymers and the chemistry that underpins their application as ophthalmic drug delivery systems.
引用
收藏
页码：2159 / 2182
页数：24
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