Temporal cytokine storm dynamics in dengue infection predicts severity

被引：13

作者：

Bhatt, Puneet ^{[1
]}

Varma, Muralidhar ^{[2
]}

Sood, Vikas ^{[3
,4
]}

Ambikan, Anoop ^{[3
]}

Jayaram, Anup ^{[1
]}

Babu, Naren ^{[1
]}

Gupta, Soham ^{[3
]}

Mukhopadhyay, Chiranjay ^{[1
,5
]}

Neogi, Ujjwal ^{[1
,3
]}

机构：

[1] Manipal Acad Higher Educ, Manipal Inst Virol, Manipal, Karnataka, India

[2] Kasturba Med Coll & Hosp, Dept Infect Dis, Manipal, Karnataka, India

[3] Karolinska Inst, Dept Lab Med, Div Clin Microbiol, Syst Virol Lab, Stockholm, Sweden

[4] Jamia Hamdard, Sch Chem & Life Sci, Dept Biochem, New Delhi, India

[5] Manipal Acad Higher Educ, Ctr Emerging & Trop Dis, Manipal, Karnataka, India

来源：

VIRUS RESEARCH | 2024年 / 341卷

基金：

瑞典研究理事会;

关键词：

Cytokine storm; Dengue severity; Temporal Analysis;

D O I：

10.1016/j.virusres.2023.199306

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The immunopathogenesis of dengue severity is convoluted. The primary objective of the research was to examine the dynamics of cytokine storm and its correlation with disease development in individuals affected by DENV infection. Additionally, the study aimed to discover potential biomarkers that could indicate severe dengue infection and determine the most suitable timeframe for predicting the severity of these biomarkers during the acute stage of dengue infections. We conducted a temporal analysis of the daily viral load and cytokine levels in 60 hospitalized dengue patients until discharge. Our findings reveal a distinct cytokine profile (elevated IL-8, IL10, IL-6, GM-CSF, MCP-1, IL-13, and IL-4 and decreased IL-12, MIP-1 beta) on the third day after symptom onset is predictive of severe dengue in secondary dengue infection. The imbalanced cytokine signature may inform clinical decision-making in treating severe dengue infections.

引用

页数：4

共 12 条

[1] Vascular Leakage in Dengue Hemorrhagic Fever Is Associated with Dengue Infected Monocytes, Monocyte Activation/Exhaustion, and Cytokines Production [J].

Chunhakan, Sirichan ;

Butthep, Punnee ;

Yoksan, Sutee ;

Tangnararatchakit, Kanchana ;

Chuansumrit, Ampaiwan .

INTERNATIONAL JOURNAL OF VASCULAR MEDICINE, 2015, 2015

[2]

Fiestas Solorzano V.E., 2022, Pathogens, V11

[3] Development of real time PCR for detection and quantitation of Dengue Viruses [J].

Gurukumar, K. R. ;

Priyadarshini, D. ;

Patil, J. A. ;

Bhagat, A. ;

Singh, A. ;

Shah, P. S. ;

Cecilia, D. .

VIROLOGY JOURNAL, 2009, 6

[4] Cytokine Expression in Dengue Fever and Dengue Hemorrhagic Fever Patients with Bleeding and Severe Hepatitis [J].

Imad, Hisham Ahmed ;

Phumratanaprapin, Weerapong ;

Phonrat, Benjaluck ;

Chotivanich, Kesinee ;

Charunwatthana, Prakaykaew ;

Muangnoicharoen, Sant ;

Khusmith, Srisin ;

Tantawichien, Terapong ;

Phadungsombat, Juthamas ;

Nakayama, Emi ;

Konishi, Eiji ;

Shioda, Tatsuo .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2020, 102 (05) :943-950

[5] IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever [J].

Karem Flores-Mendoza, Lilian ;

Estrada-Jimenez, Tania ;

Sedeno-Monge, Virginia ;

Moreno, Margarita ;

del Consuelo Manjarrez, Maria ;

Gonzalez-Ochoa, Guadalupe ;

Millan-Perez Pena, Lourdes ;

Reyes-Leyva, Julio .

MEDIATORS OF INFLAMMATION, 2017, 2017

[6] Seroprevalence of Dengue Infection Using IgG Capture ELISA in India, 2017-2018 [J].

Kumar, Muthusamy Santhosh ;

Kamaraj, P. ;

Khan, Siraj Ahmed ;

Allam, Ramesh Reddy ;

Barde, Pradip V. ;

Dwibedi, Bhagirathi ;

Kanungo, Suman ;

Mohan, Uday ;

Mohanty, Suman Sundar ;

Roy, Subarna ;

Sagar, Vivek ;

Savargaonkar, Deepali ;

Tandale, Babasaheb V. ;

Topno, Roshan Kamal ;

Kumar, C. P. Girish ;

Sabarinathan, R. ;

Kumar, V. Saravana ;

Karunakaran, T. ;

Jose, Annamma ;

Sadhukhan, Provash ;

Toteja, G. S. ;

Dutta, Shanta ;

Murhekar, Manoj .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2021, 105 (05) :1277-1280

[7] Serum Proteome and Cytokine Analysis in a Longitudinal Cohort of Adults with Primary Dengue Infection Reveals Predictive Markers of DHF [J].

Kumar, Yadunanda ;

Liang, Cui ;

Bo, Zheng ;

Rajapakse, Jagath C. ;

Ooi, Eng Eong ;

Tannenbaum, Steven R. .

PLOS NEGLECTED TROPICAL DISEASES, 2012, 6 (11)

[8] Early biomarkers for prediction of severe manifestations of dengue fever: a systematic review and a meta-analysis [J].

Moallemi, Samaneh ;

Lloyd, Andrew R. ;

Rodrigo, Chaturaka .

SCIENTIFIC REPORTS, 2023, 13 (01)

[9] Cytokine Signature Associated with Disease Severity in Dengue [J].

Patro, A. Raj Kumar ;

Mohanty, Sriprasad ;

Prusty, Birendra K. ;

Singh, Diwakar K. ;

Gaikwad, Sagar ;

Saswat, Tanuja ;

Chattopadhyay, Soma ;

Das, Bidyut K. ;

Tripathy, Rina ;

Ravindran, Balachandran .

VIRUSES-BASEL, 2019, 11 (01)

[10] Cytokine IP-10 and GM-CSF are prognostic biomarkers for severity in secondary dengue infection [J].

Sankar, S. Gowri ;

Anand, A. Alwin Prem .

HUMAN IMMUNOLOGY, 2021, 82 (06) :438-445

← 1 2 →