Chiral Gd-DOTA as a Versatile Platform for Hepatobiliary and Tumor Targeting MRI Contrast Agents

被引：7

作者：

Xu, Weiyuan ^{[1
,2
]}

Ye, Xinjian ^{[3
,4
]}

Wu, Min ^{[5
,6
]}

Jiang, Xin ^{[1
]}

Tse, Lik Hang Hugo ^{[7
]}

Gu, Yanjuan ^{[7
]}

Shu, Kun ^{[3
,4
]}

Xu, Liuhui ^{[8
]}

Jian, Yong ^{[1
]}

Mo, Gengshen ^{[1
]}

Xu, Jiao ^{[1
]}

Ding, Yinghui ^{[1
]}

Gao, Ruonan ^{[1
]}

Shen, Jianliang ^{[1
]}

Ye, Fangfu ^{[1
,2
,8
]}

Yan, Zhihan ^{[3
,4
]}

Dai, Lixiong ^{[1
,8
,9
]}

机构：

[1] Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325000, Zhejiang, Peoples R China

[2] Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325000, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Affiliated Hosp 2, Dept Radiol, Wenzhou 325027, Zhejiang, Peoples R China

[4] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China

[5] Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Funct & Mol Imaging Key Lab Sichuan Prov, Chengdu 610041, Sichuan, Peoples R China

[6] Sichuan Univ, Dept Radiol, Chengdu 610041, Sichuan, Peoples R China

[7] Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen 518057, Guangdong, Peoples R China

[8] Wenzhou Med Univ, Affiliated Hosp 1, Joint Ctr Translat Med, Wenzhou 325035, Zhejiang, Peoples R China

[9] Wenzhou Med Univ, Affiliated Hosp 2, Zhejiang Engn Res Ctr Innovat & Applicat Intellige, Wenzhou 325000, Zhejiang, Peoples R China

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 66卷 / 21期

基金：

中国国家自然科学基金;

关键词：

NEPHROGENIC SYSTEMIC FIBROSIS; CARBONIC-ANHYDRASE-IX; GADOLINIUM; STABILITY; COMPLEXES; CANCER; IMAGES; ACID;

D O I：

10.1021/acs.jmedchem.3c01183

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The leakage of gadolinium ions (Gd3+) from commercial Gd3+-based contrast agents (GBCAs) in patients is currently the major safety concern in clinical magnetic resonance imaging (MRI) scans, and the lack of task-specific GBCAs limits its usage in the early detection of disease and imaging of specific biological regions. Herein, ultrastable GBCAs were constructed via decorating chiral Gd-DOTA with a phenylic analogue to one of the pendent arms, and the stability constant was determined as high as 27.08, accompanied by negligible decomplexation in 1 M of HCl over 2 years. A hepatic-specific chiral Gd-DOTA was screened out as a potential alternative to commercial Gd-EOB-DTPA, while combination with functional molecules favored chiral Gd-DOTA as tumor targeting probes. Therefore, the novel chiral Gd-DOTA is believed to be an ideal platform for designing the next generation of GBCAs for various clinical purposes due to its outstanding inert nature.

引用

页码：14669 / 14682

页数：14

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