Genetic and Epigenetic Mechanisms of Psoriasis

被引：22
|
作者：
Mateu-Arrom, Laura [1 ]
Puig, Lluis [1 ]
机构：
[1] Univ Autonoma Barcelona, Hosp St Creu & St Pau, Inst Invest Biomed St Pau IIB SANT PAU, Dept Dermatol, Barcelona 08041, Spain
来源：
GENES | 2023年 / 14卷 / 08期
关键词：
psoriasis; genetics; epigenomics; GENOME-WIDE ASSOCIATION; NF-KAPPA-B; DNA METHYLATION; SUSCEPTIBILITY LOCI; SKIN INFLAMMATION; IDENTIFICATION; KERATINOCYTES; EXPRESSION; PROLIFERATION; AUTOIMMUNITY;
D O I：
10.3390/genes14081619
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Psoriasis is a disease involving the innate and adaptative components of the immune system, and it is triggered by environmental factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent technological advances, especially in genome and epigenome-wide studies, have provided a better understanding of the genetic and epigenetic mechanisms to determine the physiopathology of psoriasis and facilitate the development of new drugs. This review intends to summarize the current evidence on genetic and epigenetic mechanisms of psoriasis.
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页数：17
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