Nitric Oxide Signal Transduction and Its Role in Skin Sensitization

被引:10
作者
Kim, Jong Hun [1 ,2 ]
Choi, Min Sik [3 ]
机构
[1] Sungshin Womens Univ, Dept Food Sci & Biotechnol, Seoul 01133, South Korea
[2] Sungshin Womens Univ, Inst Basic Sci, Seoul 01133, South Korea
[3] Dongduk Womens Univ, Coll Pharm, Lab Pharmacol, Seoul 02748, South Korea
基金
新加坡国家研究基金会;
关键词
Nitric oxide; Skin sensitization; Contact dermatitis; PROTEIN S-NITROSYLATION; REACTIVE OXYGEN; SYNTHASE; EXPRESSION; CELLS; NO; PEROXYNITRITE; SUPEROXIDE; CHEMISTRY; INFECTION;
D O I
10.4062/biomolther.2023.101
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nitric oxide (NO) is a signaling molecule that plays a crucial role in numerous cellular physiological processes. In the skin, NO is produced by keratinocytes, fibroblasts, endothelial cells, and immune cells and is involved in skin functions such as vasodilation, pigmentation, hair growth, wound healing, and immune responses. NO modulates both innate and adaptive immune responses. As a signaling molecule and cytotoxic effector, NO influences the function of immune cells and production of cytokines. NO is a key mediator that protects against or contributes to skin inflammation. Moreover, NO has been implicated in skin sensitization, a process underlying contact dermatitis. It modulates the function of dendritic cells and T cells, thereby affecting the immune response to allergens. NO also plays a role in contact dermatitis by inducing inflammation and tissue damage. NO-related chemicals, such as nitrofatty acids and nitric oxide synthase (NOS) inhibitors, have potential therapeutic applications in skin conditions, including allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). Further research is required to fully elucidate the therapeutic potential of NO-related chemicals and develop personalized treatment strategies for skin conditions.
引用
收藏
页码:388 / 394
页数:7
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