Pax7+ Satellite Cells in Human Skeletal Muscle After Exercise: A Systematic Review and Meta-analysis

被引:6
|
作者
Dewi, Luthfia [1 ,7 ]
Lin, Yin-Chou [2 ,8 ]
Nicholls, Andrew [1 ]
Condello, Giancarlo [3 ]
Huang, Chih-Yang [4 ,5 ,6 ]
Kuo, Chia-Hua [1 ]
机构
[1] Univ Taipei, Lab Exercise Biochem, Tianmu Campus, Taipei 11153, Taiwan
[2] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Taoyuan 33378, Taiwan
[3] Univ Parma, Dept Med & Surg, I-43126 Parma, Italy
[4] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Cardiovasc & Mitochondrial Related Dis Res Ctr, Hualien 970, Taiwan
[5] Tzu Chi Univ Sci & Technol, Buddhist Tzu Chi Med Fdn, Ctr Gen Educ, Hualien 970, Taiwan
[6] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan
[7] Univ Muhammadiyah Semarang, Dept Nutr, Semarang 50273, Indonesia
[8] Open Univ Kaohsiung, Gen Educ Ctr, Kaohsiung 812, Taiwan
关键词
ENDOTHELIAL PROGENITOR CELLS; HEMATOPOIETIC STEM-CELLS; PROTEIN-SYNTHESIS; ECCENTRIC EXERCISE; FIBER HYPERTROPHY; PERIPHERAL-BLOOD; SELF-RENEWAL; YOUNG; REGENERATION; INSULIN;
D O I
10.1007/s40279-022-01767-z
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
Background Skeletal muscle has extraordinary regenerative capabilities against challenge, mainly owing to its resident muscle stem cells, commonly identified by Pax7(+), which expediently donate nuclei to the regenerating multinucleated myofibers. This local reserve of stem cells in damaged muscle tissues is replenished by undifferentiated bone marrow stem cells (CD34(+)) permeating into the surrounding vascular system. Objective The purpose of the study was to provide a quantitative estimate for the changes in Pax7(+) muscle stem cells (satellite cells) in humans following an acute bout of exercise until 96 h, in temporal relation to circulating CD34(+) bone marrow stem cells. A subgroup analysis of age was also performed. Methods Four databases (Web of Science, PubMed, Scopus, and BASE) were used for the literature search until February 2022. Pax7(+) cells in human skeletal muscle were the primary outcome. Circulating CD34(+) cells were the secondary outcome. The standardized mean difference (SMD) was calculated using a random-effects meta-analysis. Subgroup analyses were conducted to examine the influence of age, training status, type of exercise, and follow-up time after exercise. Results The final search identified 20 studies for Pax7(+) cells comprising a total of 370 participants between the average age of 21 and 74 years and 26 studies for circulating CD34(+) bone marrow stem cells comprising 494 participants between the average age of 21 and 67 years. Only one study assessed Pax7(+) cells immediately after aerobic exercise and showed a 32% reduction in exercising muscle followed by a fast repletion to pre-exercise level within 3 h. A large effect on increasing Pax7(+) cell content in skeletal muscles was observed 24 h after resistance exercise (SMD = 0.89, p < 0.001). Pax7(+) cells increased to 50% above pre-exercise level 24-72 h after resistance exercise. For a subgroup analysis of age, a large effect (SMD = 0.81, p < 0.001) was observed on increasing Pax7(+) cells in exercised muscle among adults aged> 50 years, whereas adults at younger age presented a medium effect (SMD = 0.64, p < 0.001). Both resistance exercise and aerobic exercise showed a medium overall effect in increasing circulating CD34(+) cells (SMD = 0.53, p < 0.001), which declined quickly to the pre-exercise baseline level after exercise within 6 h. Conclusions An immediate depletion of Pax7(+) cells in exercising skeletal muscle concurrent with a transient release of CD34(+) cells suggest a replenishment of the local stem cell reserve from bone marrow. A protracted Pax7(+) cell expansion in the muscle can be observed during 24-72 h after resistance exercise. This result provides a scientific basis for exercise recommendations on weekly cycles allowing for adequate recovery time. Exercise-induced Pax7(+) cell expansion in muscle remains significant at higher age, despite a lower stem cell reserve after age 50 years. More studies are required to confirm whether Pax7(+) cell increment can occur after aerobic exercise.
引用
收藏
页码:457 / 480
页数:24
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