Frontline and Relapsed Rhabdomyosarcoma (FaR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)

被引：11

作者：

Chisholm, Julia ^{[1
,2
]}

Mandeville, Henry ^{[1
,2
]}

Adams, Madeleine ^{[3
]}

Minard-Collin, Veronique ^{[4
]}

Rogers, Timothy ^{[5
]}

Kelsey, Anna ^{[6
]}

Shipley, Janet ^{[7
]}

van Rijn, Rick R. ^{[8
]}

de Vries, Isabelle ^{[9
]}

van Ewijk, Roelof ^{[9
]}

de Keizer, Bart ^{[9
]}

Gatz, Susanne A. ^{[10
,11
]}

Casanova, Michela ^{[12
]}

Hjalgrim, Lisa Lyngsie ^{[13
]}

Firth, Charlotte ^{[11
]}

Wheatley, Keith ^{[11
]}

Kearns, Pamela ^{[11
]}

Liu, Wenyu ^{[11
]}

Kirkham, Amanda ^{[11
]}

Rees, Helen ^{[14
]}

Bisogno, Gianni ^{[15
]}

Wasti, Ajla ^{[7
]}

Wakeling, Sara ^{[16
]}

Heenen, Delphine ^{[17
]}

Tweddle, Deborah A. ^{[18
]}

Merks, Johannes H. M. ^{[9
]}

Jenney, Meriel ^{[3
]}

机构：

[1] Royal Marsden Hosp, Children & Young Peoples Unit, Sutton SM2 5PT, England

[2] Inst Canc Res, Sutton SM2 5PT, England

[3] Childrens Hosp Wales, Dept Paediat Surg, Cardiff CF14 4XW, Wales

[4] Gustave Roussy, Dept Paediat Oncol, F-75015 Paris, France

[5] Univ Hosp Bristol & Weston NHS Fdn Trust, Dept Paediat Surg, Bristol BS1 3NU, England

[6] Manchester Univ NHS Fdn Trust, Royal Manchester Childrens Hosp, Dept Paediat Histopathol, Manchester M13 9WL, England

[7] Inst Canc Res, London SW7 3RP, England

[8] Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC, NL-1081 HV Amsterdam, Netherlands

[9] Princess Maxima Ctr Pediat Oncol, NL-3584 CS Utrecht, Netherlands

[10] Birmingham Womens & Childrens NHS Fdn Trust, Birmingham B15 2TG, England

[11] Univ Birmingham, Inst Canc & Genom Sci, Canc Res UK Clin Trials Unit, Birmingham B15 2TT, England

[12] Fdn IRCCS Ist Nazl Tumori, I-20133 Milan, Italy

[13] Univ Hosp Copenhagen, DK-2200 Copenhagen, Denmark

[14] Univ Hosp Bristol & Weston NHS Fdn Trust, Dept Paediat Oncol, Bristol BS1 3NU, England

[15] Univ Padua, Dept Women & Childrens Hlth, I-35122 Padua, Italy

[16] Alices Arc Charity, London EC1V 1AW, England

[17] KickCancer Fdn, B-1000 Brussels, Belgium

[18] Newcastle Univ, Translat & Clin Res Inst, Vivo Biobank, Ctr Canc, Newcastle Upon Tyne NE1 7RU, England

来源：

CANCERS | 2024年 / 16卷 / 05期

关键词：

rhabdomyosarcoma; clinical trial; chemotherapy; radiotherapy; randomisation; novel agents; FaR-RMS; EpSSG; PET RESPONSE CRITERIA; QUALITY-OF-LIFE; PHASE-II; RADIATION-THERAPY; STUDY-IV; NONMETASTATIC RHABDOMYOSARCOMA; RISK RHABDOMYOSARCOMA; INTERNATIONAL SOCIETY; PROGNOSTIC-FACTORS; YOUNG-ADULTS;

D O I：

10.3390/cancers16050998

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Frontline and Relapsed Rhabdomyosarcoma (FaR-RMS) clinical trial is an overarching, multinational study for children and adults with rhabdomyosarcoma (RMS). The trial, developed by the European Soft Tissue Sarcoma Study Group (EpSSG), incorporates multiple different research questions within a multistage design with a focus on (i) novel regimens for poor prognostic subgroups, (ii) optimal duration of maintenance chemotherapy, and (iii) optimal use of radiotherapy for local control and widespread metastatic disease. Additional sub-studies focusing on biological risk stratification, use of imaging modalities, including [F-18]FDG PET-CT and diffusion-weighted MRI imaging (DWI) as prognostic markers, and impact of therapy on quality of life are described. This paper forms part of a Special Issue on rhabdomyosarcoma and outlines the study background, rationale for randomisations and sub-studies, design, and plans for utilisation and dissemination of results.

引用

页数：24

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