Molecular complexity of intraductal carcinoma of the prostate

被引：3
作者：
Zhu, Sha [1 ]
Xu, Nanwei [1 ]
Zeng, Hao [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu 610041, Peoples R China
来源：
CANCER MEDICINE | 2024年 / 13卷 / 02期
关键词：
DNA damage and repair; Intraductal carcinoma of the prostate; MED12; molecular characteristics; MYC; NCOR2; prostate acinar adenocarcinoma; PTEN; RB1; SChLAP1; targeted therapy; TMPRSS2-ERG fusion; TP53; GLEASON PATTERN 4; TMPRSS2-ERG GENE FUSION; PTEN GENOMIC DELETION; PSA RECURRENCE; INTRAEPITHELIAL NEOPLASIA; INVASIVE ADENOCARCINOMA; RADICAL PROSTATECTOMY; HISTOLOGIC FEATURES; ANALYTIC VALIDATION; MED12; MUTATIONS;
D O I：
10.1002/cam4.6939
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Intraductal carcinoma of the prostate (IDC-P) is an aggressive subtype of prostate cancer characterized by the growth of tumor cells within the prostate ducts. It is often found alongside invasive carcinoma and is associated with poor prognosis. Understanding the molecular mechanisms driving IDC-P is crucial for improved diagnosis, prognosis, and treatment strategies. This review summarizes the molecular characteristics of IDC-P and their prognostic indications, comparing them to conventional prostate acinar adenocarcinoma, to gain insights into its unique behavior and identify potential therapeutic targets.
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页数：10
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  • [1] Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study
    Abida, Wassim
    Campbell, David
    Patnaik, Akash
    Shapiro, Jeremy D.
    Sautois, Brieuc
    Vogelzang, Nicholas J.
    Voog, Eric G.
    Bryce, Alan H.
    McDermott, Ray
    Ricci, Francesco
    Rowe, Julie
    Zhang, Jingsong
    Piulats, Josep Maria
    Fizazi, Karim
    Merseburger, Axel S.
    Higano, Celestia S.
    Krieger, Laurence E.
    Ryan, Charles J.
    Feng, Felix Y.
    Simmons, Andrew D.
    Loehr, Andrea
    Despain, Darrin
    Dowson, Melanie
    Green, Foad
    Watkins, Simon P.
    Golsorkhi, Tony
    Chowdhury, Simon
    [J]. CLINICAL CANCER RESEARCH, 2020, 26 (11) : 2487 - 2496
  • [2] The Mediator complex: a central integrator of transcription
    Allen, Benjamin L.
    Taatjes, Dylan J.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2015, 16 (03) : 155 - 166
  • [3] Clinical Features and Therapeutic Outcomes in Men with Advanced Prostate Cancer and DNA Mismatch Repair Gene Mutations
    Antonarakis, Emmanuel S.
    Shaukat, Farah
    Velho, Pedro Isaacsson
    Kaur, Harsimar
    Shenderov, Eugene
    Pardoll, Drew M.
    Lotan, Tamara L.
    [J]. EUROPEAN UROLOGY, 2019, 75 (03) : 378 - 382
  • [4] Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer
    Attard, G.
    Clark, J.
    Ambroisine, L.
    Fisher, G.
    Kovacs, G.
    Flohr, P.
    Berney, D.
    Foster, C. S.
    Fletcher, A.
    Gerald, W. L.
    Moller, H.
    Reuter, V.
    De Bono, J. S.
    Scardino, P.
    Cuzick, J.
    Cooper, C. S.
    [J]. ONCOGENE, 2008, 27 (03) : 253 - 263
  • [5] Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets
    Beltran, Himisha
    Rickman, David S.
    Park, Kyung
    Chae, Sung Suk
    Sboner, Andrea
    MacDonald, Theresa Y.
    Wang, Yuwei
    Sheikh, Karen L.
    Terry, Stephane
    Tagawa, Scott T.
    Dhir, Rajiv
    Nelson, Joel B.
    de la Taille, Alexandre
    Allory, Yves
    Gerstein, Mark B.
    Perner, Sven
    Pienta, Kenneth J.
    Chinnaiyan, Arul M.
    Wang, Yuzhuo
    Collins, Colin C.
    Gleave, Martin E.
    Demichelis, Francesca
    Nanus, David M.
    Rubin, Mark A.
    [J]. CANCER DISCOVERY, 2011, 1 (06) : 487 - 495
  • [6] Chromosomal imbalances, and immunohistochemical loss of heterozygosity, expression of TP53, RB1, and PTEN in intraductal cancer, intraepithelial neoplasia, and invasive adenocarcinoma of the prostate
    Bettendorf, Olaf
    Schmidt, Hartmut
    Staebler, Annette
    Grobholz, Rainer
    Heinecke, Achim
    Boecker, Werner
    Hertle, Lothar
    Semjonow, Axel
    [J]. GENES CHROMOSOMES & CANCER, 2008, 47 (07) : 565 - 572
  • [7] The Master Neural Transcription Factor BRN2 Is an Androgen Receptor-Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer
    Bishop, Jennifer L.
    Thaper, Daksh
    Vahid, Sepideh
    Davies, Alastair
    Ketola, Kirsi
    Kuruma, Hidetoshi
    Jama, Randy
    Nip, Ka Mun
    Angeles, Arkhjamil
    Johnson, Fraser
    Wyatt, Alexander W.
    Fazli, Ladan
    Gleave, Martin E.
    Lin, Dong
    Rubin, Mark A.
    Collins, Colin C.
    Wang, Yuzhuo
    Beltran, Himisha
    Zoubeidi, Amina
    [J]. CANCER DISCOVERY, 2017, 7 (01) : 54 - 71
  • [8] The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
    Blazek, Dalibor
    Kohoutek, Jiri
    Bartholomeeusen, Koen
    Johansen, Eric
    Hulinkova, Petra
    Luo, Zeping
    Cimermancic, Peter
    Ule, Jernej
    Peterlin, B. Matija
    [J]. GENES & DEVELOPMENT, 2011, 25 (20) : 2158 - 2172
  • [9] TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53-Mutated Prostate Cancer
    Blee, Alexandra M.
    He, Yundong
    Yang, Yinhui
    Ye, Zhenqing
    Yan, Yuqian
    Pan, Yunqian
    Ma, Tao
    Dugdale, Joseph
    Kuehn, Emily
    Kohli, Manish
    Jimenez, Rafael
    Chen, Yu
    Xu, Wanhai
    Wang, Liguo
    Huang, Haojie
    [J]. CLINICAL CANCER RESEARCH, 2018, 24 (18) : 4551 - 4565
  • [10] Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations
    Bottcher, Rene
    Kweldam, Charlotte F.
    Livingstone, Julie
    Lalonde, Emilie
    Yamaguchi, Takafumi N.
    Huang, Vincent
    Yousif, Fouad
    Fraser, Michael
    Bristow, Robert G.
    van der Kwast, Theodorus
    Boutros, Paul C.
    Jenster, Guido
    van Leenders, Geert J. L. H.
    [J]. BMC CANCER, 2018, 18
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