Adult stem cells in the eye: Identification, characterisation, and therapeutic application in ocular regeneration - A review

被引：3
作者：
Xiao, Yuting [1 ]
Mcghee, Charles N. J. [1 ]
Zhang, Jie [1 ,2 ]
机构：
[1] Univ Auckland, Fac Med & Hlth Sci, New Zealand Natl Eye Ctr, Dept Ophthalmol, Auckland, New Zealand
[2] Univ Auckland, New Zealand Natl Eye Ctr, Dept Ophthalmol, Private Bag 92019, Auckland, New Zealand
来源：
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2024年 / 52卷 / 02期
关键词：
adult stem cells; eye diseases; regeneration; stem cells; treatment; CORNEAL EPITHELIAL-CELLS; TRABECULAR MESHWORK; PROGENITOR CELLS; STEM/PROGENITOR CELLS; LACRIMAL GLAND; HAIR FOLLICLE; CILIARY BODY; CONE PHOTORECEPTORS; RETINAL ORGANOIDS; LENS REGENERATION;
D O I：
10.1111/ceo.14309
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Adult stem cells, present in various parts of the human body, are undifferentiated cells that can proliferate and differentiate to replace dying cells within tissues. Stem cells have specifically been identified in the cornea, trabecular meshwork, crystalline lens, iris, ciliary body, retina, choroid, sclera, conjunctiva, eyelid, lacrimal gland, and orbital fat. The identification of ocular stem cells broadens the potential therapeutic strategies for untreatable eye diseases. Currently, stem cell transplantation for corneal and conjunctival diseases remains the most common stem cell-based therapy in ocular clinical management. Lens epithelial stem cells have been applied in the treatment of paediatric cataracts. Several early-phase clinical trials for corneal and retinal regeneration using ocular stem cells are also underway. Extensive preclinical studies using ocular stem cells have been conducted, showing encouraging outcomes. Ocular stem cells currently demonstrate great promise in potential treatments of eye diseases. In this review, we focus on the identification, characterisation, and therapeutic application of adult stem cells in the eye.
引用
收藏
页码：148 / 166
页数：19
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