Paediatric healthcare and hospital worker SARS-CoV-2 IgG antibody: A longitudinal cohort study

被引:2
作者
Cappetto, Kaitlin D. [1 ]
Brown, Julie C. [1 ,2 ]
Englund, Janet A. [1 ,2 ]
Zerr, Danielle M. [1 ,2 ]
Dickerson, Jane A. [1 ,2 ]
Wang, Xing [1 ]
Strelitz, Bonnie [1 ]
Klein, Eileen J. [1 ,2 ]
机构
[1] Seattle Childrens Res Inst, 4800 Sand Point Way NE,Mailstop MB 7-520, Seattle, WA 98105 USA
[2] Univ Washington, Sch Med, Seattle, WA USA
来源
IJID REGIONS | 2023年 / 7卷
关键词
COVID-19; SARS-CoV-2; Serology; Paediatric; Healthcare workers;
D O I
10.1016/j.ijregi.2023.05.001
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: This study sought to determine the prevalence of severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) nucleocapsid (N) and spike (S) protein immunoglobulin G (IgG) antibodies in healthcare and hospital workers (HCHWs), and changes in IgG N antibody levels over time. Methods: Longitudinal study of HCHWs at a freestanding, urban paediatric tertiary care hospital. Asymptomatic HCHWs aged >= 18 years working in clinical areas were eligible to enrol. Participants completed four surveys and blood draws over 12 months. Specimens were tested for IgG N at four timepoints and IgG S at 12 months. Results: In total, 531 HCHWs enrolled in this study; of these, 481 (91%), 429 (81%) and 383 (72%) completed follow-up blood draws at 2, 6 and 12 months, respectively. Five of 531 (1%), 5/481 (1%), 6/429 (1%) and 5/383 (1.3%) participants were seropositive for IgG N at baseline, 2, 6 and 12 months, respectively. All (374/374; 100%) participants who received one or two doses of either mRNA COVID-19 vaccine were seropositive for IgG S. One of nine unvaccinated participants was seropositive for IgG S. Conclusions: In this paediatric hospital, IgG N and IgG S were detected in 1.9% and 97.9% of HCHWs, respectively. This study demonstrated low transmission of SARS-CoV-2 among HCHWs with appropriate infection prevention measures.
引用
收藏
页码:281 / 286
页数:6
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