Global Incidence and Prevalence of Eosinophilic Esophagitis 1976-2022: A Systematic Review and Meta-analysis

被引:64
作者
Hahn, Jong Woo [1 ,2 ]
Lee, Kwanjoo [3 ]
Shin, Jae Il [4 ]
Cho, Seong Ho [5 ]
Turner, Stephen [6 ]
Shin, Jung U. [7 ]
Yeniova, Abdullah Ozgur [8 ]
Koyanagi, Ai [9 ,10 ]
Jacob, Louis [11 ]
Smith, Lee [11 ,12 ]
Fond, Guillaume [13 ,14 ]
Boyer, Laurent [13 ,14 ]
Lee, Seung Won [15 ]
Kwon, Rosie [16 ,17 ]
Kim, Soeun [17 ]
Shin, Youn Ho [18 ]
Rhee, Sang Youl [17 ,19 ]
Moon, Jin Soo [24 ]
Ko, Jae Sung [24 ]
Yon, Dong Keon [17 ,20 ,23 ]
Papadopoulos, Nikolaos G. [21 ,22 ]
机构
[1] Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea
[2] Seoul Natl Univ, Bundang Hosp, Dept Pediat, Seongnam, South Korea
[3] CHA Univ, Digest Dis Ctr, CHA Bundang Med Ctr, Sch Med, Seongnam, South Korea
[4] Yonsei Univ, Coll Med, Dept Pediat, Seoul, South Korea
[5] Univ S Florida, Morsani Coll Med, Div Allergy Immunol, Tampa, FL USA
[6] NHS Grampian Aberdeen, Matern & Child Hlth Div, Aberdeen, Scotland
[7] CHA Univ, CHA Bundang Med Ctr, Sch Med, Dept Dermatol, Seongnam, South Korea
[8] Tokat Gaziosmanpasa Univ, Fac Med, Dept Internal Med, Div Gastroenterol, Tokat, Turkiye
[9] ISCIII, CIBERSAM, Res & Dev Unit, Parc Sanit St Joan Deu, Barcelona, Spain
[10] Pg Lluis Co, Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain
[11] Univ Versailles St Quentin en Yvelines, Fac Med, Montigny Le Bretonneux, France
[12] Anglia Ruskin Univ, Ctr Hlth Performance & Wellbeing, Cambridge, England
[13] Aix Marseille Univ, AP HM, CEReSS Hlth Serv Res & Qual Life Ctr, Marseille, France
[14] FondaMental Fdn, Creteil, France
[15] Sungkyunkwan Univ, Coll Med, Dept Precis Med, Suwon, South Korea
[16] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI USA
[17] Kyung Hee Univ, Med Sci Res Inst, Coll Med, Ctr Digital Hlth, Seoul, South Korea
[18] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Pediat, Seoul, South Korea
[19] Kyung Hee Univ, Coll Med, Dept Endocrinol & Metab, Seoul, South Korea
[20] Kyung Hee Univ, Coll Med, Dept Pediat, Seoul, South Korea
[21] Natl & Kapodistrian Univ Athens, Allergy Dept, Paediat Clin 2, Athens, Greece
[22] Univ Manchester, Fac Biol Med & Hlth, Div Immunol Immun Infect & Resp Med, Manchester, England
[23] Kyung Hee Univ, Coll Med, Dept Pediat, 23 Kyungheedae Ro, Seoul 02447, South Korea
[24] Seoul Natl Univ, Childrens Hosp, Coll Med, Dept Pediat,Div Pediat Gastroenterol Hepatol & Nut, 101 Daehak Ro, Seoul 03080, South Korea
关键词
Eosinophilic Esophagitis; Global Trend; Incidence; Prevalence; Systematic Review and Meta-analysis; CONSENSUS RECOMMENDATIONS; INCREASING INCIDENCE; RISING INCIDENCE; CHILDREN; EXPOSURES; DISEASE; ADULTS; RISK;
D O I
10.1016/j.cgh.2023.06.005
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BACKGROUND AND AIMS: Owing to 2018 expanded diagnostic criteria for eosinophilic esophagitis (EoE) and thus a possible increase in diagnosis, previous studies on the global incidence and prevalence of EoE may need to be updated. We aimed to describe global, regional, and national trends in the incidence and prevalence of EoE from 1976 to 2022 and analyze their associations with geographic, demographic, and social factors through a systematic review. METHODS: We searched the PubMed/MEDLINE, Embase, CINAHL, Google Scholar, and Cochrane databases from their inception dates to December 20, 2022, for studies that reported the incidence or prevalence of EoE in the general population. We calculated the global incidence and prevalence of EoE using pooled estimates with 95% confidence intervals (CIs) and performed subgroup analysis based on age, sex, race, geographical area, World Bank income group, and diagnostic criteria of EoE. RESULTS: Forty studies met the eligibility criteria, including over 288 million participants and 147,668 patients with EoE from 15 countries across the five continents. The global pooled incidence and prevalence of EoE were 5.31 cases per 100,000 inhabitant-years (95% CI, 3.98-6.63; number of studies, 27; sample population, 42,191,506) and 40.04 cases per 100,000 inhabitant-years (95% CI, 31.10-48.98; number of studies, 20; sample population, 30,467,177), respectively. The pooled incidence of EoE was higher in high-income countries (vs low-or middle-income countries), males, and North America (vs Europe and Asia). The global prevalence of EoE followed a similar pattern. The pooled prevalence of EoE gradually increased from 1976 to 2022 (1976-2001; 8.18; 95% CI, 3.67-12.69 vs 2017-2022; 74.42; 95% CI, 39.66-109.19 cases per 100,000 inhabitant-years). CONCLUSIONS: The incidence and prevalence of EoE have increased substantially and vary widely across the world. Further research is needed to evaluate the incidence and prevalence of EoE in Asia, South America, and Africa.
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收藏
页码:3270 / 3284.e77
页数:92
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