Venetoclax with hypomethylating agents might lead to eradication of measurable residual disease (MRD) persisting after intensive chemotherapy in acute myeloid leukemia (AML) patients with mutated NPM1 and rearranged CBF

被引：1

作者：

Jimenez-Vicente, Carlos ^{[1
,2
,3
]}

Martinez-Roca, Alexandra ^{[1
,2
]}

Pomares, Helena ^{[2
,4
]}

Castano-Diez, Sandra ^{[1
,2
]}

Guijarro, Francesca ^{[2
,5
]}

Lopez-Guerra, Monica ^{[2
,5
,6
]}

Bataller, Alex ^{[1
,2
,7
]}

Esteban, Daniel ^{[1
,2
]}

Cortes-Bullich, Albert ^{[1
,2
]}

Perez-Valencia, Amanda Isabel ^{[1
,2
]}

Guardia-Torrelles, Ares ^{[1
]}

Zugasti, Ines ^{[1
]}

Rovira, Montserrat ^{[1
,2
,3
]}

Fernandez-Aviles, Francesc ^{[1
,2
]}

Colomer, Dolors ^{[2
,5
]}

Arnan, Montserrat ^{[2
,4
]}

Diaz-Beya, Marina ^{[1
,2
,7
]}

Esteve, Jordi ^{[1
,2
,3
,7
,8
]}

机构：

[1] Hosp Clin Barcelona, Hematol Dept, Barcelona, Spain

[2] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain

[3] Univ Barcelona, Barcelona, Spain

[4] Univ Barcelona, Hosp Duran i Reynals, Inst Catala Oncol, Hematol Dept, Barcelona, Spain

[5] Hosp Clin Barcelona, Pathol Dept, Hemopathol Unit, Barcelona, Spain

[6] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain

[7] Josep Carreras Leukemia Res Inst, Barcelona, Spain

[8] Hosp Clin Barcelona, Dept Hematol, Villarroel 170, Barcelona 08036, Spain

来源：

LEUKEMIA RESEARCH | 2023年 / 135卷

关键词：

AML; Preemptive treatment; MRD; REMISSION; AZACITIDINE;

D O I：

10.1016/j.leukres.2023.107403

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页数：6

共 15 条

[1] Minimal residual disease prior to allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a meta-analysis [J].

Buckley, Sarah A. ;

Wood, Brent L. ;

Othus, Megan ;

Hourigan, Christopher S. ;

Ustun, Celalettin ;

Linden, Michael A. ;

DeFor, Todd E. ;

Malagola, Michele ;

Anthias, Chloe ;

Valkova, Veronika ;

Kanakry, Christopher G. ;

Gruhn, Bernd ;

Buccisano, Francesco ;

Devine, Beth ;

Walter, Roland B. .

HAEMATOLOGICA, 2017, 102 (05) :865-873

[2] Treatment-free remission after ceasing venetoclax-based therapy in patients with acute myeloid leukemia [J].

Chua, Chong Chyn ;

Hammond, Danielle ;

Kent, Andrew ;

Tiong, Ing Soo ;

Konopleva, Marina Y. ;

Pollyea, Daniel A. ;

DiNardo, Courtney D. ;

Wei, Andrew H. .

BLOOD ADVANCES, 2022, 6 (13) :3879-3883

[3] Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia [J].

DiNardo, C. D. ;

Jonas, B. A. ;

Pullarkat, V. ;

Thirman, M. J. ;

Garcia, J. S. ;

Wei, A. H. ;

Konopleva, M. ;

Doehner, H. ;

Letai, A. ;

Fenaux, P. ;

Koller, E. ;

Havelange, V. ;

Leber, B. ;

Esteve, J. ;

Wang, J. ;

Pejsa, V. ;

Hajek, R. ;

Porkka, K. ;

Illes, A. ;

Lavie, D. ;

Lemoli, R. M. ;

Yamamoto, K. ;

Yoon, S. -S. ;

Jang, J. -H. ;

Yeh, S. -P. ;

Turgut, M. ;

Hong, W. -J. ;

Zhou, Y. ;

Potluri, J. ;

Pratz, K. W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (07) :617-629

[4] Venetoclax combined with FLAG-IDA induction and consolidation in newly diagnosed acute myeloid leukemia [J].

DiNardo, Courtney D. ;

Lachowiez, Curtis A. ;

Takahashi, Koichi ;

Loghavi, Sanam ;

Kadia, Tapan ;

Daver, Naval ;

Xiao, Lianchun ;

Adeoti, Maria ;

Short, Nicholas J. ;

Sasaki, Koji ;

Wang, Sa A. ;

Borthakur, Gautam ;

Issa, Ghayas ;

Maiti, Abhishek ;

Alvarado, Yesid ;

Pemmaraju, Naveen ;

Bravo, Guillermo Montalban ;

Masarova, Lucia ;

Yilmaz, Musa ;

Jain, Nitin ;

Andreeff, Michael ;

Garcia-Manero, Guillermo ;

Kornblau, Steven ;

Ravandi, Farhad ;

Jabbour, Elias ;

Konopleva, Marina Y. ;

Kantarjian, Hagop M. .

AMERICAN JOURNAL OF HEMATOLOGY, 2022, 97 (08) :1035-1043

[5] Prognostic impact of NPM1 and FLT3 mutations in patients with AML in first remission treated with oral azacitidine [J].

Doehner, Hartmut ;

Wei, Andrew H. ;

Roboz, Gail J. ;

Montesinos, Pau ;

Thol, Felicitas R. ;

Ravandi, Farhad ;

Dombret, Herve ;

Porkka, Kimmo ;

Sandhu, Irwindeep ;

Skikne, Barry ;

See, Wendy L. ;

Ugidos, Manuel ;

Risueno, Alberto ;

Chan, Esther T. ;

Thakurta, Anjan ;

Beach, C. L. ;

de Menezes, Daniel Lopes .

BLOOD, 2022, 140 (15) :1674-1685

[6] Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel [J].

Doehner, Hartmut ;

Estey, Elihu ;

Grimwade, David ;

Amadori, Sergio ;

Appelbaum, Frederick R. ;

Buechner, Thomas ;

Dombret, Herve ;

Ebert, Benjamin L. ;

Fenaux, Pierre ;

Larson, Richard A. ;

Levine, Ross L. ;

Lo-Coco, Francesco ;

Naoe, Tomoki ;

Niederwieser, Dietger ;

Ossenkoppele, Gert J. ;

Sanz, Miguel ;

Sierra, Jorge ;

Tallman, Martin S. ;

Tien, Hwei-Fang ;

Wei, Andrew H. ;

Lowenberg, Bob ;

Bloomfield, Clara D. .

BLOOD, 2017, 129 (04) :424-447

[7]

Dohner H., 2022, 64 ASH ANN M EXP INT

[8] 2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party [J].

Heuser, Michael ;

Freeman, Sylvie D. ;

Ossenkoppele, Gert J. ;

Buccisano, Francesco ;

Hourigan, Christopher S. ;

Ngai, Lok Lam ;

Tettero, Jesse M. ;

Bachas, Costa ;

Baer, Constance ;

Bene, Marie-Christine ;

Bucklein, Veit ;

Czyz, Anna ;

Denys, Barbara ;

Dillon, Richard ;

Feuring-Buske, Michaela ;

Guzman, Monica L. ;

Haferlach, Torsten ;

Han, Lina ;

Herzig, Julia K. ;

Jorgensen, Jeffrey L. ;

Kern, Wolfgang ;

Konopleva, Marina Y. ;

Lacombe, Francis ;

Libura, Marta ;

Majchrzak, Agata ;

Maurillo, Luca ;

Ofran, Yishai ;

Philippe, Jan ;

Plesa, Adriana ;

Preudhomme, Claude ;

Ravandi, Farhad ;

Roumier, Christophe ;

Subklewe, Marion ;

Thol, Felicitas ;

van de Loosdrecht, Arjan A. ;

van der Reijden, Bert A. ;

Venditti, Adriano ;

Wierzbowska, Agnieszka ;

Valk, Peter J. M. ;

Wood, Brent L. ;

Walter, Roland B. ;

Thiede, Christian ;

Dohner, Konstanze ;

Roboz, Gail J. ;

Cloos, Jacqueline .

BLOOD, 2021, 138 (26) :2753-2767

[9] Outcomes of older patients with NPM1-mutated AML: current treatments and the promise of venetoclax-based regimens [J].

Lachowiez, Curtis A. ;

Loghavi, Sanam ;

Kadia, Tapan M. ;

Daver, Naval ;

Borthakur, Gautam ;

Pemmaraju, Naveen ;

Naqvi, Kiran ;

Alvarado, Yesid ;

Yilmaz, Musa ;

Short, Nicholas ;

Ohanian, Maro ;

Pierce, Sherry R. ;

Patel, Keyur P. ;

Qiao, Wei ;

Ning, Jing ;

Sasaki, Koji ;

Takahashi, Koichi ;

Jabbour, Elias ;

Andreeff, Michael ;

Ravandi, Farhad ;

Kantarjian, Hagop M. ;

Konopleva, Marina ;

DiNardo, Courtney D. .

BLOOD ADVANCES, 2020, 4 (07) :1311-1320

[10] Impact of Venetoclax and Azacitidine in Treatment-Naive Patients with Acute Myeloid Leukemia and IDH1/2 Mutations [J].

Pollyea, Daniel A. ;

DiNardo, Courtney D. ;

Arellano, Martha L. ;

Pigneux, Arnaud ;

Fiedler, Walter ;

Konopleva, Marina ;

Rizzieri, David A. ;

Smith, B. Douglas ;

Shinagawa, Atsushi ;

Lemoli, Roberto M. ;

Dail, Monique ;

Duan, Yinghui ;

Chyla, Brenda ;

Potluri, Jalaja ;

Miller, Catherine L. ;

Kantarjian, Hagop M. .

CLINICAL CANCER RESEARCH, 2022, 28 (13) :2753-2761

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