The Role of Inflammation in the Initiation and Progression of Myeloid Neoplasms

被引：25

作者：

Balandran, Juan Carlos ^{[1
,2
]}

Lasry, Audrey ^{[1
,2
,3
]}

Aifantis, Iannis ^{[1
,2
,4
]}

机构：

[1] NYU, Grossman Sch Med, Dept Pathol, New York, NY USA

[2] NYU, Grossman Sch Med, Laura & Isaac Perlmutter Canc Ctr, New York, NY USA

[3] NYU, Sch Med, Dept Pathol, 550 1st Ave,SRB1307, New York, NY 10016 USA

[4] NYU, Sch Med, Dept Pathol, 550 1st Ave,SRB1304, New York, NY 10016 USA

来源：

BLOOD CANCER DISCOVERY | 2023年 / 4卷 / 04期

关键词：

HEMATOPOIETIC STEM-CELLS; BONE-MARROW NICHE; CLONAL HEMATOPOIESIS; CHRONIC EXPOSURE; TET2; CANCER; MUTATIONS; DIFFERENTIATION; HOMEOSTASIS; HALLMARKS;

D O I：

10.1158/2643-3230.BCD-22-0176

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myeloid malignancies are devastating hematologic cancers with limited therapeutic options. Infl ammation is emerging as a novel driver of myeloid malignancy, with important implications for tumor composition, immune response, therapeutic options, and patient survival. Here, we discuss the role of infl ammation in normal and malignant hematopoiesis, from clonal hematopoiesis to full-blown myeloid leukemia. We discuss how infl ammation shapes clonal output from hematopoietic stem cells, how infl ammation alters the immune microenvironment in the bone marrow, and novel therapies aimed at targeting infl ammation in myeloid disease.Signifi cance: Infl ammation is emerging as an important factor in myeloid malignancies. Understanding the role of infl ammation in myeloid transformation, and the interplay between infl ammation and other drivers of leukemogenesis, may yield novel avenues for therapy.

引用

页码：254 / 266

页数：13

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