Shengjiang Xiexin Decoction ameliorates antibiotic-associated diarrhea by altering the gut microbiota and intestinal metabolic homeostasis

被引：16

作者：

Zhang, Cong-en ^{[1
]}

Yu, Xiao-hong ^{[1
]}

Cui, Yu-tao ^{[1
]}

Wang, Huan-jun ^{[1
]}

Chen, Xi ^{[1
]}

Ma, Xiao-jing ^{[2
]}

Li, Hui ^{[3
]}

Su, Jian-rong ^{[4
]}

Ma, Zhi-jie ^{[1
,5
]}

Huang, Lu-qi ^{[2
]}

机构：

[1] Capital Med Univ, Beijing Friendsip Hosp, Dept Pharm, Beijing 100050, Peoples R China

[2] China Acad Chinese Med Sci, Resource Ctr Chinese Mat Med, Beijing 100700, Peoples R China

[3] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

[4] Capital Med Univ, Beijing Friendship Hosp, Clin Lab Ctr, Beijing 100050, Peoples R China

[5] Capital Med Univ, Beijing Friendship Hosp, 95 Yongan Rd, Beijing 100050, Peoples R China

来源：

PHYTOMEDICINE | 2023年 / 113卷

基金：

中国国家自然科学基金;

关键词：

Antibiotic-associated diarrhea; Shengjiang Xiexin Decoction (SXD); Gut microbiota; Intestinal metabolic homeostasis; Intestinal barrier function; CLOSTRIDIUM-DIFFICILE; ESCHERICHIA-COLI; PREVENTION; BARRIER; LACTOBACILLUS; MANAGEMENT; PROBIOTICS; SHIGELLA;

D O I：

10.1016/j.phymed.2023.154737

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Background: Antibiotic-associated diarrhea (AAD) has had a significant increase in the last years, with limited available effective therapies. Shengjiang Xiexin Decoction (SXD), a classic traditional Chinese medicine formula for treating diarrhea, is a promising alternative for reducing the incidence of AAD. Purpose: This study aimed to explore the therapeutic effect of SXD on AAD and to investigate its potential therapeutic mechanism by integrated analysis of the gut microbiome and intestinal metabolic profile. Methods: 16S rRNA sequencing analysis of the gut microbiota and untargeted-metabolomics analysis of feces were performed. The mechanism was further explored by fecal microbiota transplantation (FMT). Results: SXD could effectively ameliorate AAD symptoms and restore intestinal barrier function. In addition, SXD could significantly improve the diversity of the gut microbiota and accelerate the recovery of the gut microbiota. At the genus level, SXD significantly increased the relative abundance of Bacteroides spp (p < 0.01) and decreased the relative abundance of Escherichia_Shigela spp (p < 0.001). Untargeted metabolomics showed that SXD significantly improved gut microbiota and host metabolic function, particularly bile acid metabolism and amino acid metabolism. Conclusion: This study demonstrated that SXD could extensively modulate the gut microbiota and intestinal metabolic homeostasis to treat AAD.

引用

页数：14