Rabeprazole Coadministration Controls Ulcer Recurrence in Patients on Low-dose Aspirin Therapy: A Multicenter Prospective Study

被引：1

作者：

Kinoshita, Yoshikazu ^{[1
]}

Kato, Mototsugu ^{[2
]}

Sugizaki, Katsuya ^{[3
]}

Ikeuchi, Satoshi ^{[3
]}

机构：

[1] Hyogo Prefectural Harima Himeji Gen Med Ctr, Himeji, Japan

[2] Natl Hosp Org, Hakodate Natl Hosp, Hakodate, Japan

[3] Med HQs, Eisai, Japan

来源：

INTERNAL MEDICINE | 2023年 / 62卷 / 04期

关键词：

rabeprazole; prevention of peptic ulcer; low-dose aspirin; prospective study; PROTON PUMP INHIBITORS; RANDOMIZED CLINICAL-TRIAL; DOUBLE-BLIND; GASTROINTESTINAL HEMORRHAGE; PEPTIC-ULCERS; PREVENTION; EFFICACY; RISK; ESOMEPRAZOLE; CLOPIDOGREL;

D O I：

10.2169/internalmedicine.9646-22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To evaluate the efficacy and safety of rabeprazole coadministration with low-dose aspirin (LDA).Methods From 2015 to 2018, we conducted a large-scale, multicenter, prospective observational study to assess the safety and efficacy of treatment with rabeprazole (5 or 10 mg/day) in combination with LDA.Results The incidence of adverse reactions was 0.73% (11/1,513 patients), with no serious adverse reac-tions. We found no trend toward increases in the incidence of adverse reactions with increases in treatment duration. The cumulative recurrence rate of ulcers by Week 52 (Kaplan-Meier estimates) was 3.50% (range, 1.56-7.75%). No gastrointestinal bleeding was reported.Conclusion Rabeprazole in combination with LDA appears as safe and effective in real-world situations as in clinical trials.

引用

页码：495 / 502

页数：8

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