This study evaluated the bioactivity of 3D-printed beta-tricalcium phosphate (beta-TCP) scaffolds or hydroxyapatite (HA) scaffolds associated with polydioxanone (PDO) membrane (Plenum((R)) Guide) for guided bone regeneration in rats. Fifty-four rats were divided into three groups (n = 18 animals): autogenous bone + PDO membrane (Auto/PG); 3D-printed beta-TCP + PDO membrane (TCP/PG); and 3D-printed HA + PDO membrane (HA/PG). A surgical defect in the parietal bone was made and filled with the respective scaffolds and PDO membrane. The animals were euthanized 7, 30, and 60 days after the surgical procedure for micro-CT, histomorphometric, and immunolabeling analyses. Micro-CT showed an increase in trabecular thickness and a decrease in trabecular separation, even with similar bone volume percentages between TCP/PG and HA/PG vs. Auto/PG. Histometric analysis showed increased bone formation at 30 days in the groups compared to 7 days postoperatively. Immunolabeling analysis showed an increase in proteins related to bone formation at 30 days, and both groups showed a similar immunolabeling pattern. This study concludes that 3D-printed scaffolds associated with PDO membrane (Plenum(R) Guide) present similar results to autogenous bone for bone regeneration.
机构:
Boston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
Boston Univ, Sch Dent Med, Dept Orthodont, Boston, MA 02118 USABoston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
Ai-Aql, Z. S.
;
Alagl, A. S.
论文数: 0引用数: 0
h-index: 0
机构:
King Faisal Univ, Coll Dent, Dept Prevent Dent Sci, Al Khobar 31952, Saudi ArabiaBoston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
Alagl, A. S.
;
Graves, D. T.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Dent Med, Dept Perodontol & Oral Biol, Boston, MA 02118 USABoston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
Graves, D. T.
;
Gerstenfeld, L. C.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USABoston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
Gerstenfeld, L. C.
;
Einhorn, T. A.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USABoston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
机构:
Univ Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, MalaysiaUniv Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
Bajuri, Mohd Yazid
;
Selvanathan, Nanchappan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, MalaysiaUniv Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
Selvanathan, Nanchappan
;
Dzeidee Schaff, Fatin Nadira
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, MalaysiaUniv Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
Dzeidee Schaff, Fatin Nadira
;
Abdul Suki, Muhammad Haziq
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, MalaysiaUniv Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
Abdul Suki, Muhammad Haziq
;
Ng, Angela Min Hwei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kebangsaan Malaysia Med Ctr UKMMC, Tissue Engn Ctr, Jalan Yaacob Latif, Kuala Lumpur 56000, MalaysiaUniv Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
机构:
Univ Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, AustraliaUniv Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
Batoon, Lena
;
Millard, Susan Marie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, AustraliaUniv Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
Millard, Susan Marie
;
Raggatt, Liza Jane
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
Univ Queensland, Fac Med, Herston, Qld 4092, AustraliaUniv Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
Raggatt, Liza Jane
;
Pettit, Allison Robyn
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
Univ Queensland, Fac Med, Herston, Qld 4092, AustraliaUniv Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
机构:
Brown Univ, Miriam Hosp, Warren Alpert Med Sch, Dept Plast Surg, Providence, RI 02903 USA
Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Plast Surg, Providence, RI 02903 USAHarvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Orthopaed, Boston, MA 02215 USA
Bhatt, Reena A.
;
Rozental, Tamara D.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Orthopaed, Boston, MA 02215 USAHarvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Orthopaed, Boston, MA 02215 USA
机构:
Beth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Bouxsein, Mary L.
;
Boyd, Stephen K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calgary, Dept Mech Engn, Schulich Sch Engn, Calgary, AB T2N 1N4, CanadaBeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Boyd, Stephen K.
;
Christiansen, Blaine A.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Christiansen, Blaine A.
;
Guldberg, Robert E.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Inst Technol, George W Woodruff Sch Mech Engn, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USABeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Guldberg, Robert E.
;
Jepsen, Karl J.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Orthopaed, New York, NY USABeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Jepsen, Karl J.
;
Mueller, Ralph
论文数: 0引用数: 0
h-index: 0
机构:
Swiss Fed Inst Technol, Inst Biomech, Zurich, SwitzerlandBeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
机构:
Univ Malaya, Fac Dent, Kuala Lumpur 50603, MalaysiaUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
Cheah, Chia Wei
;
Al-Namnam, Nisreen Mohammed
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Fac Med Sci, Sch Dent Sci, Framlington Pl, Newcastle Upon Tyne NE2 4BW, Tyne & Wear, EnglandUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
Al-Namnam, Nisreen Mohammed
;
论文数: 引用数:
h-index:
机构:
Lau, May Nak
;
Lim, Ghee Seong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Malaya, Fac Dent, Kuala Lumpur 50603, MalaysiaUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
Lim, Ghee Seong
;
Raman, Renukanth
论文数: 0引用数: 0
h-index: 0
机构:
Minist Hlth Malaysia, Oral Hlth Div, Putrajaya 62590, MalaysiaUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
Raman, Renukanth
;
Fairbairn, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Detroit Mercy, Sch Dent, Dept Periodontol & Implant Dent, 2700 Martin Luther King,Jr Blvd, Detroit, MI 48208 USAUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
Fairbairn, Peter
;
Ngeow, Wei Cheong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Malaya, Fac Dent, Kuala Lumpur 50603, MalaysiaUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
机构:
Boston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
Boston Univ, Sch Dent Med, Dept Orthodont, Boston, MA 02118 USABoston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
Ai-Aql, Z. S.
;
Alagl, A. S.
论文数: 0引用数: 0
h-index: 0
机构:
King Faisal Univ, Coll Dent, Dept Prevent Dent Sci, Al Khobar 31952, Saudi ArabiaBoston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
Alagl, A. S.
;
Graves, D. T.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Dent Med, Dept Perodontol & Oral Biol, Boston, MA 02118 USABoston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
Graves, D. T.
;
Gerstenfeld, L. C.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USABoston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
Gerstenfeld, L. C.
;
Einhorn, T. A.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USABoston Univ, Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Res Lab, Boston, MA 02118 USA
机构:
Univ Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, MalaysiaUniv Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
Bajuri, Mohd Yazid
;
Selvanathan, Nanchappan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, MalaysiaUniv Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
Selvanathan, Nanchappan
;
Dzeidee Schaff, Fatin Nadira
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, MalaysiaUniv Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
Dzeidee Schaff, Fatin Nadira
;
Abdul Suki, Muhammad Haziq
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, MalaysiaUniv Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
Abdul Suki, Muhammad Haziq
;
Ng, Angela Min Hwei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kebangsaan Malaysia Med Ctr UKMMC, Tissue Engn Ctr, Jalan Yaacob Latif, Kuala Lumpur 56000, MalaysiaUniv Kebangsaan Malaysia Med Ctr UKMMC, Dept Orthoped & Traumatol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia
机构:
Univ Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, AustraliaUniv Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
Batoon, Lena
;
Millard, Susan Marie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, AustraliaUniv Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
Millard, Susan Marie
;
Raggatt, Liza Jane
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
Univ Queensland, Fac Med, Herston, Qld 4092, AustraliaUniv Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
Raggatt, Liza Jane
;
Pettit, Allison Robyn
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
Univ Queensland, Fac Med, Herston, Qld 4092, AustraliaUniv Queensland, Bones & Immunol Lab, Canc Biol & Care Program, Mater Res Inst,Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia
机构:
Brown Univ, Miriam Hosp, Warren Alpert Med Sch, Dept Plast Surg, Providence, RI 02903 USA
Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Plast Surg, Providence, RI 02903 USAHarvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Orthopaed, Boston, MA 02215 USA
Bhatt, Reena A.
;
Rozental, Tamara D.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Orthopaed, Boston, MA 02215 USAHarvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Orthopaed, Boston, MA 02215 USA
机构:
Beth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Bouxsein, Mary L.
;
Boyd, Stephen K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calgary, Dept Mech Engn, Schulich Sch Engn, Calgary, AB T2N 1N4, CanadaBeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Boyd, Stephen K.
;
Christiansen, Blaine A.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Christiansen, Blaine A.
;
Guldberg, Robert E.
论文数: 0引用数: 0
h-index: 0
机构:
Georgia Inst Technol, George W Woodruff Sch Mech Engn, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USABeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Guldberg, Robert E.
;
Jepsen, Karl J.
论文数: 0引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Orthopaed, New York, NY USABeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
Jepsen, Karl J.
;
Mueller, Ralph
论文数: 0引用数: 0
h-index: 0
机构:
Swiss Fed Inst Technol, Inst Biomech, Zurich, SwitzerlandBeth Israel Deaconess Med Ctr, Orthoped Biomech Lab RN115, Ctr Adv Orthoped Studies, Boston, MA 02215 USA
机构:
Univ Malaya, Fac Dent, Kuala Lumpur 50603, MalaysiaUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
Cheah, Chia Wei
;
Al-Namnam, Nisreen Mohammed
论文数: 0引用数: 0
h-index: 0
机构:
Newcastle Univ, Fac Med Sci, Sch Dent Sci, Framlington Pl, Newcastle Upon Tyne NE2 4BW, Tyne & Wear, EnglandUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
Al-Namnam, Nisreen Mohammed
;
论文数: 引用数:
h-index:
机构:
Lau, May Nak
;
Lim, Ghee Seong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Malaya, Fac Dent, Kuala Lumpur 50603, MalaysiaUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
Lim, Ghee Seong
;
Raman, Renukanth
论文数: 0引用数: 0
h-index: 0
机构:
Minist Hlth Malaysia, Oral Hlth Div, Putrajaya 62590, MalaysiaUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
Raman, Renukanth
;
Fairbairn, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Detroit Mercy, Sch Dent, Dept Periodontol & Implant Dent, 2700 Martin Luther King,Jr Blvd, Detroit, MI 48208 USAUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia
Fairbairn, Peter
;
Ngeow, Wei Cheong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Malaya, Fac Dent, Kuala Lumpur 50603, MalaysiaUniv Malaya, Fac Dent, Kuala Lumpur 50603, Malaysia